Ammonium chiral borate salt catalyzed asymmetric Friedel-Crafts alkylation of indoles with alpha,beta-disubstituted enals

Abstract

In, the presence of a catalytic amount of ammonium chiral borate salt, asymmetric Friedel-Crafts alkylation of indoles with alpha,beta-disubstituted enals proceeded to give the corresponding 1,4-addition products with moderate enantioselectivities. (C) 2017 Elsevier Ltd. All rights reserved.