Formal Synthesis of 3-Deoxy-D-manno-Octulosonic Acid (KDO) and 3-Deoxy-D-arabino-2-heptulosonic Acid (DAH)

Title:	Formal Synthesis of 3-Deoxy-D-manno-Octulosonic Acid (KDO) and 3-Deoxy-D-arabino-2-heptulosonic Acid (DAH)
Authors:	Pradhan, Tapan Kumar Lin, Chun Cheng Mong, Kwok Kong Tony 應用化學系 Department of Applied Chemistry
Keywords:	carbohydrates;Wittig;Corey-Fuchs;cyclization
Issue Date:	1-Jan-2013
Abstract:	Practical synthetic routes to 3-deoxy-D-manno-octulo-sonic acid (KDO) and 3-deoxy-D-arabino-2-heptulosonic acid (DAH) from common sugar substrates are reported. Chain homologation of the sugar substrates was accomplished by Wittig olefination and Corey-Fuchs alkynylation. A new cyclization strategy was investigated to access the desired pyranosyl isomer of the KDO target.
URI:	http://dx.doi.org/10.1055/s-0032-1317932 http://hdl.handle.net/11536/21295
ISSN:	0936-5214
DOI:	10.1055/s-0032-1317932
Journal:	SYNLETT
Volume:
Issue:	2
Begin Page:	219
End Page:	222
Appears in Collections:	Articles

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