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dc.contributor.authorLin, Chien Y.en_US
dc.contributor.authorHuang, Jung Y.en_US
dc.contributor.authorLo, Leu-Weien_US
dc.date.accessioned2015-07-21T11:21:01Z-
dc.date.available2015-07-21T11:21:01Z-
dc.date.issued2014-12-07en_US
dc.identifier.issn0021-9606en_US
dc.identifier.urihttp://dx.doi.org/10.1063/1.4902985en_US
dc.identifier.urihttp://hdl.handle.net/11536/124079-
dc.description.abstractWe developed an energetic model by integrating the generalized Langevin equation with the Cahn-Hilliard equation to simulate the diffusive behaviors of receptor proteins in the plasma membrane of a living cell. Simulation results are presented to elaborate the confinement effects from actin corrals and protein-induced lipid domains. Single-molecule tracking data of epidermal growth factor receptors (EGFR) acquired on live HeLa cells agree with the simulation results and the mechanism that controls the diffusion of single-molecule receptors is clarified. We discovered that after ligand binding, EGFR molecules move into lipid nanodomains. The transition rates between different diffusion states of liganded EGFR molecules are regulated by the lipid domains. Our method successfully captures dynamic interactions of receptors at the single-molecule level and provides insight into the functional architecture of both the diffusing EGFR molecules and their local cellular environment. (C) 2014 AIP Publishing LLC.en_US
dc.language.isoen_USen_US
dc.titleEnergetic modeling and single-molecule verification of dynamic regulation on receptor complexes by actin corrals and lipid raft domainsen_US
dc.typeArticleen_US
dc.identifier.doi10.1063/1.4902985en_US
dc.identifier.journalJOURNAL OF CHEMICAL PHYSICSen_US
dc.citation.volume141en_US
dc.citation.issue21en_US
dc.contributor.department光電工程學系zh_TW
dc.contributor.departmentDepartment of Photonicsen_US
dc.identifier.wosnumberWOS:000346014200051en_US
dc.citation.woscount1en_US
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