標題: | Thermodynamic Insight into Protein Aggregation Using a Kinetic Ising Model |
作者: | Tsai, Min-Yeh Yuan, Jian-Min Lin, Sheng-Hsien 應用化學系 Department of Applied Chemistry |
關鍵字: | Protein aggregation;Thermodynamics;Kinetics;Ising model |
公開日期: | 1-一月-2015 |
摘要: | In this work, we present a kinetic analysis for protein aggregation using the kinetic Ising model, which serves as a new application of a previously proposed model [Liang et al., J. Chin. Chem. Soc. 2003, 50, 335]. Considering protein as a single spin unit, we map two states of a unit to the aggregation-prone (AP) and the fibril (F) states. This work shows that the model can successfully capture the nucleation-growth features of protein aggregation from experiments, which offers thermodynamic interpretations of aggregation properties, such as lag-time and fibril stability. |
URI: | http://dx.doi.org/10.1002/jccs.201400272 http://hdl.handle.net/11536/124243 |
ISSN: | 0009-4536 |
DOI: | 10.1002/jccs.201400272 |
期刊: | JOURNAL OF THE CHINESE CHEMICAL SOCIETY |
Volume: | 62 |
起始頁: | 21 |
結束頁: | 25 |
顯示於類別: | 期刊論文 |