標題: On the study of BSA-loaded calcium-deficient hydroxyapatite nano-carriers for controlled drug delivery
作者: Liu, TY
Chen, SY
Liu, DM
Liou, SC
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: nano-carrier;aspect ratio;in-situ process;calcium-deficient hydroxyapatite;BSA;release behaviors
公開日期: 20-九月-2005
摘要: Calcium-deficient hydroxyapatite (CDHA) nano-crystals incorporated with bovine serum albumin (BSA) to form BSA-loaded nano-carriers were synthesized via both in-situ and ex-situ processes. Amount of BSA uptake by the CDHA nanocrystals and subsequent release behaviors of the BSA-loaded nano-carriers were investigated. The amount of BSA uptake by CDHA decreases with increasing pH but a larger amount was observed in the ex-situ compared to in-situ process above pH = 8.0. The release profile showed a bursting behavior for the nano-carrier prepared via the ex-situ process, which is probably due to the desorption of BSA molecules. In contrast, for the sample synthesized via the in-situ process at a higher pH level, a slower release profile without bursting behavior due to the dissolution of the BSA-incorporated CDHA crystal is seen from high solution TEM that indicates different extent of interaction between BSA and CDHA. On the other hand, for the nano-carriers prepared via the same process at lower pH level, a two-stage release profile was detected. An initial bursting release is due to the desorption of BSA from the CDHA surface, followed by a slow release as a result of the dissolution of the BSA-incorporated nano-crystals along its c-axis direction. (c) 2005 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jconrel.2005.05.025
http://hdl.handle.net/11536/13259
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2005.05.025
期刊: JOURNAL OF CONTROLLED RELEASE
Volume: 107
Issue: 1
起始頁: 112
結束頁: 121
顯示於類別:期刊論文


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