標題: | Nucleobase-Functionalized Supramolecular Micelles with Tunable Physical Properties for Efficient Controlled Drug Release |
作者: | Cheng, Chih-Chia Lin, I-Hong Chen, Jem-Kun Liao, Zhi-Sheng Huang, Jyun-Jie Lee, Duu-Jong Xin, Zhong 應用化學系 Department of Applied Chemistry |
關鍵字: | biocomplementary interaction;controlled-release drug delivery;pH-responsive micelle;self-assembly;supramolecular polymer |
公開日期: | 十月-2016 |
摘要: | Complementary nucleobase-functionalized polymeric micelles, a combination of adenine-thymine (A-U) base pairs and a blend of hydrophilic-hydrophobic polymer pairs, can be used to construct 3D supramolecular polymer networks; these micelles exhibit excellent self-assembly ability in aqueous solution, rapid pH-responsiveness, high drug loading capacity, and triggerable drug release. In this study, a multi-uracil functionalized poly(epsilon-caprolactone) (U-PCL) and adenine end-capped difunctional oligomeric poly(ethylene glycol) (BA-PEG) are successfully developed and show high affinity and specific recognition in solution owing to dynamically reversible A-U-induced formation of physical cross-links. The U-PCL/BA-PEG blend system produces supramolecular micelles that can be readily adjusted to provide the desired critical micellization concentration, particle size, and stability. Importantly, in vitro release studies show that doxorubicin (DOX)-loaded micelles exhibit excellent DOX-encapsulated stability under physiological conditions. When the pH value of the solution is reduced from 7.4 to 5.0, DOX-loaded micelles can be rapidly triggered to release encapsulated DOX, suggesting these polymeric micelles represent promising candidate pH-responsive nanocarriers for controlled-release drug delivery and pharmaceutical applications. |
URI: | http://dx.doi.org/10.1002/mabi.201600189 http://hdl.handle.net/11536/132651 |
ISSN: | 1616-5187 |
DOI: | 10.1002/mabi.201600189 |
期刊: | MACROMOLECULAR BIOSCIENCE |
Volume: | 16 |
Issue: | 10 |
起始頁: | 1415 |
結束頁: | 1421 |
顯示於類別: | 期刊論文 |