標題: | An enzymatic approach to configurationally rare trans-androsteronyl--glucoside and Its potential anticancerapplication |
作者: | Chou, Feng-Pai Tsai, Chia-Tse Chiou, Ya-Sheng Chen, Yi-Ju Li, Meng-Erh Guo, Ting-Wei Lyu, Jason WenJay Chou, Sheng-Hao Wu, Tung-Kung 生物科技學系 Department of Biological Science and Technology |
關鍵字: | glycosyltransferase;Helicobacter pylori;MCF-7 breast cancer cell;steroid -glucoside;sterol |
公開日期: | 一月-2017 |
摘要: | Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl--glucosides. Investigation of trans-androsteronyl--glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl--glucosides with useful biological activities. |
URI: | http://dx.doi.org/10.1111/cbdd.12830 http://hdl.handle.net/11536/132958 |
ISSN: | 1747-0277 |
DOI: | 10.1111/cbdd.12830 |
期刊: | CHEMICAL BIOLOGY & DRUG DESIGN |
Volume: | 89 |
Issue: | 1 |
起始頁: | 61 |
結束頁: | 66 |
顯示於類別: | 期刊論文 |