An enzymatic approach to configurationally rare trans-androsteronyl--glucoside and Its potential anticancerapplication

doi:10.1111/cbdd.12830

Title:	An enzymatic approach to configurationally rare trans-androsteronyl--glucoside and Its potential anticancerapplication
Authors:	Chou, Feng-Pai Tsai, Chia-Tse Chiou, Ya-Sheng Chen, Yi-Ju Li, Meng-Erh Guo, Ting-Wei Lyu, Jason WenJay Chou, Sheng-Hao Wu, Tung-Kung 生物科技學系 Department of Biological Science and Technology
Keywords:	glycosyltransferase;Helicobacter pylori;MCF-7 breast cancer cell;steroid -glucoside;sterol
Issue Date:	Jan-2017
Abstract:	Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl--glucosides. Investigation of trans-androsteronyl--glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl--glucosides with useful biological activities.
URI:	http://dx.doi.org/10.1111/cbdd.12830 http://hdl.handle.net/11536/132958
ISSN:	1747-0277
DOI:	10.1111/cbdd.12830
Journal:	CHEMICAL BIOLOGY & DRUG DESIGN
Volume:	89
Issue:	1
Begin Page:	61
End Page:	66
Appears in Collections:	Articles