標題: Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell Adhesion and Proliferation
作者: Liu, Jie
Sun, Ziling
Yuan, Yuqi
Tian, Xin
Liu, Xi
Duan, Guangxin
Yang, Yonggang
Yuan, Lin
Lin, Hsin-Chieh
Li, Xinming
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: hydrogel;peptide;self-assembly;supramolecular;glycopeptide
公開日期: 23-三月-2016
摘要: Glycopeptide-based hydrogelators with well-defined molecular structures and, varied contents of sugar moieties were prepared via in vitro peptide glycosylation reactions. With systematic glucose modification, these glycopeptide hydrogelators exhibited diverse self-assembling behaviors in water and formed supramolecular hydrogels with enhanced thermostability and biostability, in comparison with their peptide analogue. Moreover, because of high water content and similar structural morphology and composition to extracellular matrixes (ECM) in tissues, these self-assembled hydrogels also exhibited great potential to act as anew biomimetic scaffolds for mammalian cell growth. Therefore, peptide glycosylation proved to be an effective means for peptide modification and generation of novel supramolecular hydrogelators/hydrogels with improved biophysical properties (e.g., high biostability, increased thermostability, and cell adhesion) which could promise potential applications in regenerative medicine.
URI: http://dx.doi.org/10.1021/acsami.6b00850
http://hdl.handle.net/11536/133463
ISSN: 1944-8244
DOI: 10.1021/acsami.6b00850
期刊: ACS APPLIED MATERIALS & INTERFACES
Volume: 8
Issue: 11
起始頁: 6917
結束頁: 6924
顯示於類別:期刊論文