標題: | Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell Adhesion and Proliferation |
作者: | Liu, Jie Sun, Ziling Yuan, Yuqi Tian, Xin Liu, Xi Duan, Guangxin Yang, Yonggang Yuan, Lin Lin, Hsin-Chieh Li, Xinming 材料科學與工程學系 Department of Materials Science and Engineering |
關鍵字: | hydrogel;peptide;self-assembly;supramolecular;glycopeptide |
公開日期: | 23-三月-2016 |
摘要: | Glycopeptide-based hydrogelators with well-defined molecular structures and, varied contents of sugar moieties were prepared via in vitro peptide glycosylation reactions. With systematic glucose modification, these glycopeptide hydrogelators exhibited diverse self-assembling behaviors in water and formed supramolecular hydrogels with enhanced thermostability and biostability, in comparison with their peptide analogue. Moreover, because of high water content and similar structural morphology and composition to extracellular matrixes (ECM) in tissues, these self-assembled hydrogels also exhibited great potential to act as anew biomimetic scaffolds for mammalian cell growth. Therefore, peptide glycosylation proved to be an effective means for peptide modification and generation of novel supramolecular hydrogelators/hydrogels with improved biophysical properties (e.g., high biostability, increased thermostability, and cell adhesion) which could promise potential applications in regenerative medicine. |
URI: | http://dx.doi.org/10.1021/acsami.6b00850 http://hdl.handle.net/11536/133463 |
ISSN: | 1944-8244 |
DOI: | 10.1021/acsami.6b00850 |
期刊: | ACS APPLIED MATERIALS & INTERFACES |
Volume: | 8 |
Issue: | 11 |
起始頁: | 6917 |
結束頁: | 6924 |
顯示於類別: | 期刊論文 |