標題: | Structural and Functional Test Methods for Micro-Electrode-Dot-Array Digital Microfluidic Biochips |
作者: | Li, Zipeng Lai, Kelvin Yi-Tse Yu, Po-Hsien Chakrabarty, Krishnendu Ho, Tsung-Yi Lee, Chen-Yi 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics |
關鍵字: | Dependability;digital microfluidics;microelectrode-dot-array (MEDA);reconfiguration;testing |
公開日期: | 1-五月-2018 |
摘要: | A digital microfluidic biochip (DMFB) is an attractive platform for immunoassays, point-of-care clinical diagnostics, DNA sequencing, and other laboratory procedures in biochemistry. More recently, DMFBs based on a micro-electrode-dot-array (MEDA) architecture have been proposed, and droplet manipulations on MEDA biochips have also been experimentally demonstrated. In order to ensure robust fluidic operations and high confidence in the outcome of biochemical experiments, MEDA biochips must be adequately tested before they can be used for bioassay execution. This paper presents the first approach for testing of MEDA biochips that include both CMOS circuits and microfluidic components. We first present structural test techniques to evaluate the pass/fail status of each microcell (droplet actuation, droplet maintenance, and droplet sensing) and identify faulty microcells. In order to ensure correct operation of functional units, e.g., mixers and diluters, we also present functional test techniques to address fundamental MEDA operations, such as droplet dispensing, transportation, mixing, and splitting. We evaluate the proposed test methods using simulations as well as experiments for fabricated MEDA biochips. |
URI: | http://dx.doi.org/10.1109/TCAD.2017.2740299 http://hdl.handle.net/11536/144898 |
ISSN: | 0278-0070 |
DOI: | 10.1109/TCAD.2017.2740299 |
期刊: | IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS |
Volume: | 37 |
起始頁: | 968 |
結束頁: | 981 |
顯示於類別: | 期刊論文 |