標題: | Early-life arsenic exposure promotes atherogenic lipid metabolism in adolescence: A 15-year birth cohort follow-up study in central Taiwan |
作者: | Kuo, Chin-Chi Su, Pen-Hua Sun, Chien-Wen Liu, Huei-Ju Chang, Chaw-Liang Wang, Shu-Li 生物科技學系 Department of Biological Science and Technology |
關鍵字: | Arsenic;Lipid profile;Birth cohort;Trajectory;Glucose metabolism;Insulin resistance |
公開日期: | 1-九月-2018 |
摘要: | Background: Inorganic arsenic (iAs) exposure potentially causes diabetes and cardiovascular diseases in adults. However, its effect on glucose and lipid metabolism in early life remains unknown. Objective: We evaluated the associations between early-life arsenic exposure and profiles of glucose and lipids in a 15-year birth cohort in central Taiwan. Methods: We studied 237 adolescents through 5 waves of follow-up interviews and examinations at ages of approximately 2, 5, 8, 11, and 14 y. We obtained at least one follow-up urine measurement for arsenic species and blood sample collection up to 14 y of age and identified group-based trajectories of serial iAs by semi-parametric mixture modeling. Multiple linear and logistic regressions were performed to assess the effect of the arsenic exposure trajectory on serum fasting glucose, total cholesterol (TCHO), triglycerides (TGs), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). Results: Three trajectories of postnatal arsenic exposure were identified, namely stable-low (31.4%), stable-high (48.2%), and rising-high (20.4%) groups. Compared with the stable-low trajectory group, the percent changes in TCHO and LDL was 14% (95% confidence interval 4-24%) and 23% (9-38%) for the group with "rising-high" trajectory and was 8% (-1-16%) and 16% (4-29%) for the group with "stable-high" trajectory. The rising-high group was also associated with an increase in the TCHO/HDL ratio by 14% (95% CI 3%-25%). The adjusted odds ratios of high developmental trajectories of TCHO, TG, LDL, and non-HDL levels were 4.0 (95% CI 1.2-13.7), 12.2 (2.2-67), 7.3 (1.8-30), and 3.6 (0.9-14.6), respectively, in the rising-high group (reference: stable-low group). Conclusion: Our findings suggest that conversion to an atherogenic lipid profile in adolescents may be associated with early-life exposure to environmental arsenic, particularly during the pre-adolescent period. An environmental modification approach for preventing As-related cardiovascular disease is recommended to begin early in life. |
URI: | http://dx.doi.org/10.1016/j.envint.2018.05.033 http://hdl.handle.net/11536/145245 |
ISSN: | 0160-4120 |
DOI: | 10.1016/j.envint.2018.05.033 |
期刊: | ENVIRONMENT INTERNATIONAL |
Volume: | 118 |
起始頁: | 97 |
結束頁: | 105 |
顯示於類別: | 期刊論文 |