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dc.contributor.authorPrabhu, Gurpur Rakesh D.en_US
dc.contributor.authorWitek, Henryk A.en_US
dc.contributor.authorUrban, Pawel L.en_US
dc.date.accessioned2019-04-02T05:59:37Z-
dc.date.available2019-04-02T05:59:37Z-
dc.date.issued2018-08-07en_US
dc.identifier.issn0003-2654en_US
dc.identifier.urihttp://dx.doi.org/10.1039/c7an01926ben_US
dc.identifier.urihttp://hdl.handle.net/11536/147899-
dc.description.abstractMost analytical methods are based on analogue inputs from sensors of light, electric potentials, or currents. The signals obtained by such sensors are processed using certain calibration functions to determine concentrations of the target analytes. The signal readouts are normally done after an optimised and fixed time period, during which an assay mixture is incubated. This minireview covers anotherand somewhat unusualanalytical strategy, which relies on the measurement of time interval between the occurrences of two distinguishable states in the assay reaction. These states manifest themselves via abrupt changes in the properties of the assay mixture (e.g. change of colour, appearance or disappearance of luminescence, change in pH, variations in optical activity or mechanical properties). In some cases, a correlation between the time of appearance/disappearance of a given property and the analyte concentration can be also observed. An example of an assay based on time measurement is an oscillating reaction, in which the period of oscillations is linked to the concentration of the target analyte. A number of chemo-chronometric assays, relying on the existing (bio)transformations or artificially designed reactions, were disclosed in the past few years. They are very attractive from the fundamental point of view butso faronly few of them have be validated and used to address real-world problems. Then, can chemo-chronometric assays become a practical tool for chemical analysis? Is there a need for further development of such assays? We are aiming to answer these questions.en_US
dc.language.isoen_USen_US
dc.titleChemical clocks, oscillations, and other temporal effects in analytical chemistry: oddity or viable approach?en_US
dc.typeArticleen_US
dc.identifier.doi10.1039/c7an01926ben_US
dc.identifier.journalANALYSTen_US
dc.citation.volume143en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000439586400001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles