標題: Temperature-Controlled Thiation of alpha-Cyano-beta-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2-Aminothiophenes and Thieno[2,3-c]isothiazoles
作者: Kao, Tzu-Ting
Peng, Bo-Kai
Liang, Min-Chieh
Lee, Chia-Jui
Chen, I-Chia
Shia, Kak-Shan
Wu, Yen-Ku
應用化學系
Department of Applied Chemistry
公開日期: 7-十二月-2018
摘要: Making use of temperature-controlled thiation as a key operation, a simple route to 2-aminothiophenes or thieno[2,3-c]isothiazoles has been newly developed wherein the 2-aminothiophene nucleus was formed through an initial formation of thioamide followed by a 5-exo-dig addition to the tethered alkyne; however, under harsher thermal conditions, excess sulfur-transferring reagents enabled further oxidative thiation to generate the corresponding thieno[2,3-c]isothiazoles.
URI: http://dx.doi.org/10.1021/acs.joc.8b01866
http://hdl.handle.net/11536/148589
ISSN: 0022-3263
DOI: 10.1021/acs.joc.8b01866
期刊: JOURNAL OF ORGANIC CHEMISTRY
Volume: 83
起始頁: 14688
結束頁: 14697
顯示於類別:期刊論文