標題: MULTICHANNEL PLANAR MICROELECTRODE ARRAY FOR SOMATIC MAPPING IN RATS
作者: Shaw, Fu-Zen
Yang, Tsung-Fu
Huang, Chien-Chun
Yeh, Keng-Hung
Chang, Tao-Chih
Leu, Fang-Jun
友訊交大聯合研發中心
D Link NCTU Joint Res Ctr
關鍵字: Microelectrode;Somatotopic map;MEMS;Planar;Array
公開日期: 1-十二月-2011
摘要: Planar electrode array is an important tool to evaluate perceptual or cognitive functions of the cortex and prosthetic applications. Many construction methods have been developed. To maximize the usefulness of an array electrode, a low-cost, precise, and flexible microelectrode array with low man power and short construction duration is crucial. In this study, we introduced an 8 x 8 microelectrode array on a flexible polyimide film through microelectronics fabrication. The array dimension was capable of covering the primary somatosensory cortex of a rat. The microelectrode array was insulated with biocompatible Parylene-C except of microelectrode tip. Each electrode tip was 66 mu m height and separated with 0.5 mm to refine a detail somatic sensory processing. In pentobarbital anesthetized rats, stable spontaneous brain activity was successfully recorded through the electrode array. In addition, positive peaks of somatosensory evoked potentials (SEPs) elicited by stimulating rat's whisker pad, forepaw, hindpaw, and tail were obviously and consistently recorded. Latencies of SEPs increased as caudal part of the body was stimulated. The SEPs from stimulation of 4 body parts revealed different spatiotemporal patterns, which indicated a somatotopic organization of the rat. Our results demonstrated the superiority of the planar microelectrode array on the application of simultaneous recording and analysis of the brain activity in rats.
URI: http://dx.doi.org/10.1142/S1016237211002840
http://hdl.handle.net/11536/15374
ISSN: 1016-2372
DOI: 10.1142/S1016237211002840
期刊: BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS
Volume: 23
Issue: 6
起始頁: 501
結束頁: 508
顯示於類別:期刊論文