標題: Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan
作者: Zhang, Han-Wei
Kok, Victor C.
Chuang, Shu-Chun
Tseng, Chun-Hung
Lin, Chin-Teng
Li, Tsai-Chung
Sung, Fung-Chang
Wen, Chi P.
Hsiung, Chao A.
Hsu, Chung Y.
電機工程學系
腦科學研究中心
Department of Electrical and Computer Engineering
Brain Research Center
關鍵字: Alzheimer's disease;dementia;hydrocarbons;air pollution;environmental pollutants;population-based
公開日期: 1-一月-2019
摘要: Background: Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger a dementia event. Objective: We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the risk of developing dementia. Method: The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox proportional hazards regression analysis was used to fit the multiple pollutant models for two targeted pollutants, including total hydrocarbons and non-methane hydrocarbons, and estimated the risk of dementia. Results: Before controlling for multiple pollutants, hazard ratios with 95% confidence intervals for the overall population were 7.63 (7.28-7.99, p <0.001) at a 0.51 -ppm increases in total hydrocarbons, and 2.94 (2.82-3.05, p <0.001) at a 0.32-ppm increases in non-methane hydrocarbons. The highest adjusted hazard ratios for different multiple-pollutant models of each targeted pollutant were statistically significant (p <0.001) for all patients: 11.52 (10.86-12.24) for total hydrocarbons and 9.73 (9.18-10.32) for non-methane hydrocarbons. Conclusion: Our findings suggest that total hydrocarbons and non-methane hydrocarbons may be contributing to dementia development.
URI: http://dx.doi.org/10.2174/1567205017666200103112443
http://hdl.handle.net/11536/153778
ISSN: 1567-2050
DOI: 10.2174/1567205017666200103112443
期刊: CURRENT ALZHEIMER RESEARCH
Volume: 16
Issue: 14
起始頁: 1276
結束頁: 1289
顯示於類別:期刊論文