標題: | Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan |
作者: | Zhang, Han-Wei Kok, Victor C. Chuang, Shu-Chun Tseng, Chun-Hung Lin, Chin-Teng Li, Tsai-Chung Sung, Fung-Chang Wen, Chi P. Hsiung, Chao A. Hsu, Chung Y. 電機工程學系 腦科學研究中心 Department of Electrical and Computer Engineering Brain Research Center |
關鍵字: | Alzheimer's disease;dementia;hydrocarbons;air pollution;environmental pollutants;population-based |
公開日期: | 1-一月-2019 |
摘要: | Background: Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger a dementia event. Objective: We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the risk of developing dementia. Method: The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox proportional hazards regression analysis was used to fit the multiple pollutant models for two targeted pollutants, including total hydrocarbons and non-methane hydrocarbons, and estimated the risk of dementia. Results: Before controlling for multiple pollutants, hazard ratios with 95% confidence intervals for the overall population were 7.63 (7.28-7.99, p <0.001) at a 0.51 -ppm increases in total hydrocarbons, and 2.94 (2.82-3.05, p <0.001) at a 0.32-ppm increases in non-methane hydrocarbons. The highest adjusted hazard ratios for different multiple-pollutant models of each targeted pollutant were statistically significant (p <0.001) for all patients: 11.52 (10.86-12.24) for total hydrocarbons and 9.73 (9.18-10.32) for non-methane hydrocarbons. Conclusion: Our findings suggest that total hydrocarbons and non-methane hydrocarbons may be contributing to dementia development. |
URI: | http://dx.doi.org/10.2174/1567205017666200103112443 http://hdl.handle.net/11536/153778 |
ISSN: | 1567-2050 |
DOI: | 10.2174/1567205017666200103112443 |
期刊: | CURRENT ALZHEIMER RESEARCH |
Volume: | 16 |
Issue: | 14 |
起始頁: | 1276 |
結束頁: | 1289 |
顯示於類別: | 期刊論文 |