標題: | Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models |
作者: | Jaw, Twei-Shiun Chen, Shih-Hsien Wang, Yun-Ming Hsu, Jui-Sheng Kuo, Yu-Ting Chiu, Yen-Yu Tsai, Kun-Bow Hsieh, Tsyh-Jyi Liu, Gin-Chung 生物科技學系 Department of Biological Science and Technology |
關鍵字: | Magnetic resonance imaging;Contrast agents;Hepatobiliary |
公開日期: | 1-三月-2012 |
摘要: | To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies. Copyright (C) 2012, Elsevier Taiwan LLC. All rights reserved. |
URI: | http://hdl.handle.net/11536/16131 |
ISSN: | 1607-551X |
期刊: | KAOHSIUNG JOURNAL OF MEDICAL SCIENCES |
Volume: | 28 |
Issue: | 3 |
結束頁: | 130 |
顯示於類別: | 期刊論文 |