Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor

標題:	Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor
作者:	Huang, Chi-Chieh Hsu, Hsin-Feng Chen, Sz-Hau Tsai, Kun-Yu Huang, Yang-Tung Lin, Chih-Sheng Hsu, Shih-Hsin 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics
關鍵字:	SPR;surface plasmon resonance;sensor
公開日期:	2012
摘要:	In this paper, real-time characterization of alpha-thrombin binding to single-strand DNA (ssDNA) aptamers by novel Si-based waveguide SPR biosensors has been investigated. The gold nanoparticles (AuNPs) modified with anti-thrombin antibodies were employed to bind with alpha-thrombin via strong antibody/antigen affinity for SPR signal amplification. The detection limit of 1 pM for alpha-thrombin detection was achieved.
URI:	http://hdl.handle.net/11536/16228 http://dx.doi.org/83512R
ISBN:	978-0-8194-9027-8
ISSN:	0277-786X
DOI:	83512R
期刊:	THIRD ASIA PACIFIC OPTICAL SENSORS CONFERENCE
Volume:	8351
顯示於類別：	會議論文

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