標題: | Computation of brain neurodegeneration in the Alzheimer's fly - art. no. 61433E |
作者: | Lee, P. C. Huang, Y. R. Chang, H. M. Chiang, A. S. Ching, Y. T. 資訊工程學系 Department of Computer Science |
關鍵字: | confocal microscopic images;matched filter;alpha-shape;active-contour;snake |
公開日期: | 2006 |
摘要: | Expression of human A beta 42 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A beta 42 flies. Here, we report a three-dimensional computation algorisin allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, alpha-shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A beta. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease. |
URI: | http://hdl.handle.net/11536/17137 http://dx.doi.org/10.1117/12.653069 |
ISBN: | 0-8194-6186-5 |
ISSN: | 0277-786X |
DOI: | 10.1117/12.653069 |
期刊: | Medical Imaging 2006: Physiology, Function, and Structure from Medical Images Pts 1 and 2 |
Volume: | 6143 |
起始頁: | E1433 |
結束頁: | E1433 |
顯示於類別: | 會議論文 |