標題: Computation of brain neurodegeneration in the Alzheimer's fly - art. no. 61433E
作者: Lee, P. C.
Huang, Y. R.
Chang, H. M.
Chiang, A. S.
Ching, Y. T.
資訊工程學系
Department of Computer Science
關鍵字: confocal microscopic images;matched filter;alpha-shape;active-contour;snake
公開日期: 2006
摘要: Expression of human A beta 42 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A beta 42 flies. Here, we report a three-dimensional computation algorisin allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, alpha-shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A beta. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease.
URI: http://hdl.handle.net/11536/17137
http://dx.doi.org/10.1117/12.653069
ISBN: 0-8194-6186-5
ISSN: 0277-786X
DOI: 10.1117/12.653069
期刊: Medical Imaging 2006: Physiology, Function, and Structure from Medical Images Pts 1 and 2
Volume: 6143
起始頁: E1433
結束頁: E1433
顯示於類別:會議論文


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