Sequential [3+2] and [4+2] Cycloadditions for Stereoselective Synthesis of a Novel Polyheterocyclic Scaffold

Abstract

A strategy of combining [3 + 2] cycloaddition and intramolecular Diels-Alder reaction is developed for the [3 + 2] cycloaddition of azomethine ylides and maleimides were derivatized for intramolecular Diels-Alder reaction of furan to form highly condensed heterocyclic products as racemic single diastereomers.