標題: | Template-based scoring functions for visualising biological insights of H-2K(b)-peptide-TCR complexes |
作者: | Liu, I-Hsin Lo, Yu-Shu Yang, Jinn-Moon 生物資訊及系統生物研究所 Institude of Bioinformatics and Systems Biology |
關鍵字: | MHC;major histocompatibility complex;TCR;T-cell receptor;template-based scoring function;peptide |
公開日期: | 2013 |
摘要: | Major Histocompatibility Complex (MHC), peptide and T-Cell Receptor (TCR) play an essential role of adaptive immune responses. Many prediction servers are available for identification of peptides that bind to MHC class I molecules but often lack detailed interacting residues for analysing MHC-peptide-TCR interaction mechanisms. This study considers both the interface similarity and the interacting force for identifying binding models. Our model, considering both the MHC-peptide and the peptide-TCR interfaces, is able to provide visualisation and the biological insights of binding models. We believe that our model is useful for the development of peptide-based vaccines. |
URI: | http://hdl.handle.net/11536/22826 http://dx.doi.org/10.1504/IJDMB.2013.056079 |
ISSN: | 1748-5673 |
DOI: | 10.1504/IJDMB.2013.056079 |
期刊: | INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS |
Volume: | 8 |
Issue: | 3 |
起始頁: | 326 |
結束頁: | 337 |
顯示於類別: | 期刊論文 |