標題: Template-based scoring functions for visualising biological insights of H-2K(b)-peptide-TCR complexes
作者: Liu, I-Hsin
Lo, Yu-Shu
Yang, Jinn-Moon
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: MHC;major histocompatibility complex;TCR;T-cell receptor;template-based scoring function;peptide
公開日期: 2013
摘要: Major Histocompatibility Complex (MHC), peptide and T-Cell Receptor (TCR) play an essential role of adaptive immune responses. Many prediction servers are available for identification of peptides that bind to MHC class I molecules but often lack detailed interacting residues for analysing MHC-peptide-TCR interaction mechanisms. This study considers both the interface similarity and the interacting force for identifying binding models. Our model, considering both the MHC-peptide and the peptide-TCR interfaces, is able to provide visualisation and the biological insights of binding models. We believe that our model is useful for the development of peptide-based vaccines.
URI: http://hdl.handle.net/11536/22826
http://dx.doi.org/10.1504/IJDMB.2013.056079
ISSN: 1748-5673
DOI: 10.1504/IJDMB.2013.056079
期刊: INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS
Volume: 8
Issue: 3
起始頁: 326
結束頁: 337
顯示於類別:期刊論文