標題: | A "turn on/off" scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy |
作者: | Chen, Chung-An Wang, Chun-Chi Chen, Yen-Ling Jong, Yuh-Jyh Wu, Shou-Mei 生物科技學院 College of Biological Science and Technology |
公開日期: | 2014 |
摘要: | A "turn on/off\'\' biosensor for diagnosis of exon 7 of the SMN1 gene was developed by employing a "scorpion primer\'\'. This scorpion primer was based on the principle of fluorescence resonance energy transfer using a fluorophore, a blocker and a quencher. It was successfully applied to detect 10 volunteer samples, and not only to in vitro testing. |
URI: | http://hdl.handle.net/11536/24568 http://dx.doi.org/10.1039/c4cc03472d |
ISSN: | 1359-7345 |
DOI: | 10.1039/c4cc03472d |
期刊: | CHEMICAL COMMUNICATIONS |
Volume: | 50 |
Issue: | 59 |
起始頁: | 8069 |
結束頁: | 8072 |
顯示於類別: | 期刊論文 |