標題: | A Bayesian clustering approach for detecting gene-gene interactions in high-dimensional genotype data |
作者: | Chen, Sui-Pi Huang, Guan-Hua 統計學研究所 Institute of Statistics |
關鍵字: | Dirichlet process mixtures;epistasis;permutation test;stochastic search |
公開日期: | 1-六月-2014 |
摘要: | This paper uses a Bayesian formulation of a clustering procedure to identify gene-gene interactions under case-control studies, called the Algorithm via Bayesian Clustering to Detect Epistasis (ABCDE). The ABCDE uses Dirichlet process mixtures to model SNP marker partitions, and uses the Gibbs weighted Chinese restaurant sampling to simulate posterior distributions of these partitions. Unlike the representative Bayesian epistasis detection algorithm BEAM, which partitions markers into three groups, the ABCDE can be evaluated at any given partition, regardless of the number of groups. This study also develops permutation tests to validate the disease association for SNP subsets identified by the ABCDE, which can yield results that are more robust to model specification and prior assumptions. This study examines the performance of the ABCDE and compares it with the BEAM using various simulated data and a schizophrenia SNP dataset. |
URI: | http://dx.doi.org/10.1515/sagmb-2012-0074 http://hdl.handle.net/11536/24695 |
ISSN: | 2194-6302 |
DOI: | 10.1515/sagmb-2012-0074 |
期刊: | STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY |
Volume: | 13 |
Issue: | 3 |
起始頁: | 275 |
結束頁: | 297 |
顯示於類別: | 期刊論文 |