標題: | Finding regularity in various types of secondary protein structures |
作者: | Chu, YW Yang, JM 生物科技學系 資訊工程學系 Department of Biological Science and Technology Department of Computer Science |
關鍵字: | secondary protein structure;schema;steady-state genetic algorithm;rule extraction;sequence alignment;substitution matrix;voting mechanism;sequential pattern |
公開日期: | 1-十一月-2003 |
摘要: | Protein function is structurally determined, but analyzing the structure of a protein is both difficult and time-consuming. The authors look at the natural instincts of protein secondary structures, which used to be analyzed in terms of their statistical relationship with a single amino acid. Several schemas are offered for identifying regular patterns among various types of secondary protein structures. The schemas employ genetic algorithms based on a steady-state strategy. Two disjunctive data sets were used to verify fitness. The paper concludes with some illustrations of significant schemas produced as part of this study, with brief explanations of their significance. |
URI: | http://hdl.handle.net/11536/27422 |
ISSN: | 1016-2364 |
期刊: | JOURNAL OF INFORMATION SCIENCE AND ENGINEERING |
Volume: | 19 |
Issue: | 6 |
起始頁: | 943 |
結束頁: | 952 |
顯示於類別: | 期刊論文 |