標題: | Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer |
作者: | Wu, Yao-Kuang Chen, Kuei-Tien Kuo, Yung-Bin Huang, Ya-Shu Chan, Err-Cheng 生物科技學系 Department of Biological Science and Technology |
關鍵字: | Survivin expression;Pleural effusion;Survival rate;Prognosis;Lung cancer |
公開日期: | 18-一月-2009 |
摘要: | in the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.canlet.2008.08.023 http://hdl.handle.net/11536/7738 |
ISSN: | 0304-3835 |
DOI: | 10.1016/j.canlet.2008.08.023 |
期刊: | CANCER LETTERS |
Volume: | 273 |
Issue: | 2 |
起始頁: | 331 |
結束頁: | 335 |
顯示於類別: | 期刊論文 |