標題: | Integrating epidemic dynamics with daily commuting networks: building a multilayer framework to assess influenza A (H1N1) intervention policies |
作者: | Tsai, Yu-Shiuan Huang, Chung-Yuan Wen, Tzai-Hung Sun, Chuen-Tsai Yen, Muh-Yong 教育研究所 資訊工程學系 Institute of Education Department of Computer Science |
關鍵字: | computer simulation;epidemic dynamics;geographic information system;multilayer model;travel network |
公開日期: | 1-五月-2011 |
摘要: | We describe an innovative simulation framework that combines daily commuting network data with a commonly used population-based transmission model to assess the impacts of various interventions on epidemic dynamics in Taiwan. Called the Multilayer Epidemic Dynamics Simulator (MEDSim), our proposed framework has four contact structures: within age group, between age groups, daily commute, and nationwide interaction. To test model flexibility and generalizability, we simulated outbreak locations and intervention scenarios for the 2009 swine-origin influenza A (H1N1) epidemic. Our results indicate that lower transmission rates and earlier intervention activation times did not reduce total numbers of infected cases, but did delay peak times. When the transmission rate was decreased by a minimum of 70%, significant epidemic peak delays were observed when interventions were activated before new case number 50; no significant effects were noted when the transmission rate was decreased by less than 30%. Observed peaks occurred more quickly when initial outbreaks took place in urban rather than rural areas. According to our results, the MEDSim provides insights that reflect the dynamic processes of epidemics under different intervention scenarios, thus clarifying the effects of complex contact structures on disease transmission dynamics. |
URI: | http://dx.doi.org/10.1177/0037549710379481 http://hdl.handle.net/11536/8962 |
ISSN: | 0037-5497 |
DOI: | 10.1177/0037549710379481 |
期刊: | SIMULATION-TRANSACTIONS OF THE SOCIETY FOR MODELING AND SIMULATION INTERNATIONAL |
Volume: | 87 |
Issue: | 5 |
起始頁: | 385 |
結束頁: | 405 |
顯示於類別: | 期刊論文 |