標題: Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase: A Chemistry-Biology Interdisciplinary Study of the Protein's Structure-Function-Reaction Mechanism Relationships
作者: Wu, Tung-Kung
Chang, Cheng-Hsiang
Liu, Yuan-Ting
Wang, Tsai-Ting
生物科技學系
Department of Biological Science and Technology
關鍵字: oxidosqualene cyclase;biomimetic;site-saturated mutagenesis;molecular evolution;protein engineering;protein plasticity
公開日期: 2008
摘要: The oxidosqualene cyclases (EC 5.4.99-) constitute a family of enzymes that catalyze diverse cyclization/rearrangement reactions of (3S)-2,3-oxidosqualene into a distinct array of sterols and triterpenes. The relationship between the cyclization mechanism and the enzymatic structure is extremely complex and compelling. This review covers the historical achievements of biomimetic studies and current progress in structural biology, molecular genetics, and bioinformatics studies to elucidate the mechanistic and structure-function relationships of the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase-catalyzed cyclization/rearrangement reaction. (C) 2008 The Japan Chemical journal Forum and Wiley Periodicals, Inc. Chem Rec 8: 302-325; 2008: Published online in Wiley, InterScience (www.interscience.wiley.com) DOI 10. 1002/tcr.20157
URI: http://hdl.handle.net/11536/9787
http://dx.doi.org/10.1002/tcr.20157
ISSN: 1527-8999
DOI: 10.1002/tcr.20157
期刊: CHEMICAL RECORD
Volume: 8
Issue: 5
起始頁: 302
結束頁: 325
顯示於類別:期刊論文


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