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Browsing by Author "Adak, Avijit Kumar"

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    trans-Stilbene C-Glycosides: Synthesis by a Microwave-Assisted Heck Reaction and Evaluation of the SGLT-2 Inhibitory Activity
    (2017-09-01)
    Ponnapalli, Kalyana Kumar
    ;
    Adak, Avijit Kumar
    ;
    Das, Anindya
    ;
    Song, Jen-Shin
    ;
    Wu, Szu-Huei
    A protocol for the microwave-assisted Heck coupling reaction of C-aryl glycosides and styrenes has been developed for the synthesis of mono-and bis(C-glycoside) stilbenes. This method exclusively provides C-glycoside trans-stilbenes in good yields. The Pd-catalyzed Heck coupling re-action was successfully applied to various functionalized C-glycosyl aryl iodides and various substituted styrenes to deliver several C-glycoside trans-stilbenes with high selectivity. The obtained C-glycosyl trans-stilbenes were also examined for human SGLT-2 inhibitory activity.