Browsing by Author "Chang, C."

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Brain nociceptive imaging in rats using F-18-fluorodeoxyglucose small-animal positron emission tomography
(2008-09-09)
Shih, Y. -Y. I.
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Chiang, Y. -C.
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Chen, J. -C.
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Huang, C. -H.
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Chen, Y. -Y.
Preclinical exploration of pain processing in the brain as well as evaluating pain-relief drugs in small animals embodies the potential biophysical effects in humans. However, it is difficult to measure nociception-related cerebral metabolic changes in vivo, especially in unanesthetized animals. The present study used F-18-fluorodeoxyglucose small-animal positron emission tomography to produce cerebral metabolic maps associated with formalin-induced nociception. Anesthesia was not applied during the uptake period so as to reduce possible confounding effects on pain processing in the brain. The formalin stimulation at the hind paw of rats resulted in significant metabolic increases in the bilateral cingulate cortex, motor cortex, primary somatosensory cortex, secondary somatosensory cortex, insular cortex, visual cortex, caudate putamen, hippocampus, periaqueductal gray, amygdala, thalamus, and hypothalamus. Among the measured areas, clear lateralization was only evident in the primary somatosensory cortex and hypothalamus. In addition, pretreatment with lidocaine (4 mg/kg, i.v.) and morphine (10 mg/kg, i.v.) significantly suppressed formalin-induced cerebral metabolic increases in these areas. The present protocol allowed identification of the brain areas involved in pain processing, and should be useful in further evaluations of the effects of new drugs and preclinical therapies for pain. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
Detection of chymase activity using the AuNPs-peptide probe, a specific peptide probe conjugated onto gold nanoparticles
(2018-07-01)
Sun, Y.
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Yeh, F.
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Tseng, I.
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Chang, C.
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Chen, C.
Low frequency noise characterization of CoFeB/MgO/CoFeB MTJ based perpendicular field sensor.
(2015)
Lee, Y.
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Das, B.
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Li, L.
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Suen, Y.
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Horng, L.
Novel Electromagnetic Targeting System for Navigating Surgery in Endobronchoscopy
(2018-01-01)
Chen, C.
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Lin, C.
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Cheng, Y.
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Chung, T.
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Chang, C.
Rapid Synthesis of Semipolar ZnO Nanorod Arrays on M-Sapphire by Microwave-Assisted Chemical Bath Deposition
(2018-01-01)
Tsai, C. J.
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Do, H.
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Chang, C.
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Chiu, K. A.
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Hsiang, C. C.
Microwave-assisted chemical bath deposition (CBD) is a newly developed technique for fast growth of single-crystalline ZnO nanorods in a solution containing zinc nitrate at temperature below 100 degrees C. ZnO nanorods have many applications for devices, however, semipolar oriented ZnO nanorods have been rarely reported. In this study, epitaxial growth of well-aligned arrays of inclined semipolar ZnO nanorods on a ZnO seed layer on m-plane sapphire substrates is successfully fabricated by using microwave-assisted chemical bath deposition for 10 min at 90 degrees C. TEM analysis reveals that The ZnO nanorods have an inclined angle about 30 degrees with m-sapphire surface and an average length about 500 nm which gives a growth rate of 3 mu m/h. Micro-photoluminescence measurements show that ZnO nanorods are of a reasonably good quality.
Role of chymase on the disease progression of diabetic nephropathy might via STAT3 signaling pathway
(2018-07-01)
Cho, C.
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Wang, G.
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Xie, X.
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Wu, H.
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Chang, C.