Browsing by Author "Chang, Cheng-Chung"

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LABEL-FREE SENSOR
(2010-09-23)
Meng, Hsin- Fei
;
Hong, Sheng-Fu
;
Chao, Yu-Chiang
;
Liu, Chien-Cheng
;
Liu, Wen-Hsing
A label-free sensor is disclosed. The label-free sensor comprises a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and is in contact with the first electrode and the second electrode, wherein the semiconductor layer has a plurality of probe groups, which are bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance, which has bonding specificity with the probe groups. The semiconductor layer of the label-free sensor of the present invention is bonded with probe groups, and the detection of detected object is performed in instant, quick, rapid, and sensitive manner by measuring variation in electric current, thereby avoiding the use of the fluorescent reading equipment for reading fluorescent signals.
Selective real-time nitric oxide detection by functionalized zinc oxide
(2009-08-07)
Liu, Chien-Cheng
;
Li, Jan-Hao
;
Chang, Cheng-Chung
;
Chao, Yu-Chiang
;
Meng, Hsin-Fei
Ferriprotoporphyrin IX chloride (haemin)-functionalized Al-doped zinc oxide (ZnO) is used for nitric oxide (NO) sensing at room temperature. The devices show high selectivity to NO against CO(2) and O(2). There is no such selectivity without haemin. Porous ZnO film made by a polystyrene sphere template is used to provide a high surface area. In comparison with non-porous ZnO film with low surface area, both the sensitivity and the response speed of the sensor made by porous ZnO are clearly improved. NO concentration down to 1 ppm can be detected. The response time is 20 s. The sensor is reversible after purging with pure nitrogen for about 100 s. Such a device is able to detect real-time variation of NO which is a vital physiological signalling molecule.