Browsing by Author "Chang, Ming-Hsien"

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Evaluation of traumatic brain injury by optical technique
(2015-10-14)
Lin, Bor-Shyh
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Wang, Che-Chuan
;
Chang, Ming-Hsien
;
Chio, Chung-Ching
;
光電系統研究所
Background: Traumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death. However, there is paucity of information regarding changes in the physiologic state of humans or animals after brain shaking. Methods: In this study, near-infrared spectroscopy (NIRS) was used to continuously monitor the concentration change of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) to understand changes in the physiological state during and after brain shaking. Laser Doppler flowmetry was also used to monitor changes in cerebral blood flow under TBI to supplement the investigation. Triphenyltetrazolium chloride (TTC) staining was used to monitor changes of infarction volume corresponding to different impact strengths. Result: The experimental results indicated that concentration changes of HbO2 and total-hemoglobin (HbT) were significantly related to the impact strength. The infarction volume was also significantly related to the impact strength. Conclusion: Therefore, the non-invasive monitoring of concentration changes in HbO2, HbR, and HbT using NIRS may have a clinical application for the evaluation of TBI.
Near-infrared Spectroscopy System for Determining Brain Hemoglobin Level
(2013)
Wu, Pei-Jung
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Chang, Ming-Hsien
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Huang, Cheng-Yang
;
Wang, Yu-Cheng
;
Kuo, Jinn-Rung
Traumatic brain injury (TBI) usually results from brain shaking or impact. It can affect the normal function of the brain and even cause people become disabled and death. However, there is lack of studies for the physiological changes of humans or animals under brain injury. In order to obtain the information of physiological state change, we designed and enforced a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) for monitoring the concentration change of oxy-hemoglobin (HbO(2)), deoxy-hemoglobin (HbR) and total-hemoglobin (HbT) continuously during and after TBI. The experimental results indicated that the concentration change of HbO(2) and HbT is significantly related to the impact strength and infarction volume. Thus, this system is easily used and stable for TBI study.
Wireless near-infrared spectroscopy system for determining brain hemoglobin levels in laboratory animals
(2013-04-15)
Kuo, Jinn-Rung
;
Chang, Ming-Hsien
;
Wang, Che-Chuan
;
Chio, Chung-Ching
;
Wang, Jhi-Joung
Traumatic brain injury (TBI) is usually caused by brain shaking or impact. It can affect normal brain function and may even lead to disability or death. However, there are very few studies on the associated physiologic changes in humans or animals. In this study, a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) was developed to continuously monitor the concentration change of oxyhemoglobin (HbO(2)), deoxyhemoglobin (HbR), and total hemoglobin (HbT) to elucidate changes in the physiological state of the brain during and after different strength impaction. The triphenyltetrazolium chloride (TTC) staining was also used to monitor changes of infarction volume after different strength impaction. The results indicated that the concentration changes of HbO(2) and HbT, and the changes of infarction volumes were significantly related to the impact strength. In conclusion, the status of TBI can be clinically evaluated by detecting HbO(2) and HbT changes. The system proposed here is stable, accurate, non-invasive, and mostly important wireless which can easily be used for TBI study. (C) 2013 Elsevier B.V. All rights reserved.