Browsing by Author "Chang, Pei-Yu"

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EMBRYO LAB CHIP TAKING ADVANTAGE OF MICROFLUIDICS AND CELL CO-CULTURING
(2015)
Liu, Cheng-Hsien
;
Chang, Kuo-Wei
;
Chang, Pei-Yu
;
Sung, Yi-Jung
;
Huang, Hong-Yuan
This research serves as an in vitro platform for fertilization and embryonic development. Thin polydimethylsiloxane ( PDMS) membrane was etched to create an array of through-holes, and sandwiched between two PDMS channels to form an upper chamber and lower chamber. This device integrates the concentration gradient design and perfusion system for proposed embryo coculture with stromal cells.
Fabrication of 3D Microfluidic Chip integrating Concentration gradient design and Perfusion system for Embryo coculture with Stromal cells
(2012-01-01)
Chang, Pei-Yu
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Chang, Kuo-Wei
;
Lin, Ciou-Wen
;
Shih, Po-Chen
;
Liu, Cheng-Hsien
Fabrication of 3D chip that enables cell culture under continuous flow perfusion and repeated in situ observation by light microscopy is described. Thin polydimethylsiloxane PDMS) membrane was etched to create an array of through-holes, and sandwiched between two PDMS channels to form an upper chamber and lower chamber. Thus we fabricated a 3D microfluidic chip which integrates the concentration gradient design and perfusion system for proposed embryo coculture with stromal cells.
Socially optimal and fund-balanced advanced recycling fees and subsidies in a competitive forward and reverse supply chain
(2014-01-01)
Hong, I-Hsuan
;
Lee, Yi-Ting
;
Chang, Pei-Yu
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工業工程與管理學系
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Department of Industrial Engineering and Management
Advanced recycling fees (ARFs) and government subsidy fees are important for curtailing the consumption of new products and encouraging recycling and disposal of end-of-life (EOL) products. We introduce a model consisting of a leader (the Environmental Protection Agency, EPA) and two groups of followers (MIS firms and recyclers) consisting of manufacturers, importers and sellers, and recyclers which compete in both consuming and recycling markets. The EPA determines the ARFs paid by the MIS firms and the fees subsidizing recyclers to maximize the social welfare in closed-loop supply chains where the MIS firms and recyclers attempt to maximize their respective profit functions. To compare with current practice, we describe a conceptual fund balance model to determine the ARF and subsidy fee on the basis of the balance between total collected ARFs and expenditure of subsidies. Using numerical examples for the laptop computer market in Taiwan, we demonstrate that our results outperform the current practice. (C) 2013 Elsevier B.V. All rights reserved.
Womb-on-a-chip biomimetic system for improved embryo culture and development
(2016-04-01)
Chang, Kuo-Wei
;
Chang, Pei-Yu
;
Huang, Hong-Yuan
;
Li, Chin-Jung
;
Tien, Chang-Hung
The 3D biomimetic microsystem described in this research integrates various functions of the fallopian tube to serve as an in vitro platform for fertilization and embryonic development. This device mimics the in vivo embryo-endometrial stromal cell monolayer coculture to enhance the group culture of embryos and mechanically culture the embryos in a dynamic manner to enhance their development. The microdevice presented here is compared with static culture for embryonic development rate in the presence and absence of epithelial cells. The results suggest that the dynamic biomimetic microsystem enhances the rate of embryo development, providing a culture environment that closely mimics the in vivo microenvironment. This all-in-one biomimetic microsystem has the potential to replace the present embryo culture platforms used for assisting in vitro fertilization. (C) 2015 Elsevier B.V. All rights reserved.