Browsing by Author "Chang, Tsung-Che"

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Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
(2013)
Lin, Chien-Hung
;
Chang, Tsung-Che
;
Das, Anindya
;
Fang, Ming-Yu
;
Hung, Hui-Chen
A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.