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Browsing by Author "Chang, Ying-Sheng"

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    One-Pot, Two-Step Synthesis of Imidazo[1,2-a]benzimidazoles via A Multicomponent [4+1] Cycloaddition Reaction
    (2013-10-01)
    Hsiao, Ya-Shan
    ;
    Narhe, Bharat D.
    ;
    Chang, Ying-Sheng
    ;
    Sun, Chung-Ming
    ;
    應用化學系
    A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.