Browsing by Author "Chang, Yu-Chuan"

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A 77-GHz 2T6R Transceiver With Injection-Lock Frequency Sextupler Using 65-nm CMOS for Automotive Radar System Application
(2016-10)
Hsiao, Yuan-Hung
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Chang, Yu-Chuan
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Tsai, Ching-Han
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Huang, Ting-Yi
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Aloui, Sofiane
In this paper, a CMOS multichannel transceiver (TRX) is proposed for angular identification in automotive car radar applications. Two transmitters (TXs) and six receivers (RXs) are placed on the same die using 65-nm CMOS technology with chip size 3.5x3 mm(2). To generate a millimeter-wave (MMW) frequency-modulated continuous-wave signal, an injection-lock frequency sextupler cascaded a 1-to-8 Wilkinson power dividing network with wideband isolation is designed as the LO-chain to convert external source from 12.5-13.7 to 75-82.2 GHz for both the TXs and RXs. Each TX achieves above 11-dBm output power and the RXs achieve 30-dB conversion gain from 75 to 82 GHz, and the total power dissipation of whole chip is 1.43 W. Compared with other published multichannel TRXs in silicon germanium (SiGe) process, this paper demonstrates compatible performances and the potential of multichannel TRX using CMOS for MMW automotive car radar application.
Boundary influence on the entropy of a Lozi-type map
(2010-11-15)
Juang, Jonq
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Chang, Yu-Chuan
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應用數學系
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數學建模與科學計算所(含中心)
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Department of Applied Mathematics
Let T be a Henon-type map induced from a spatial discretization of a reaction-diffusion system. With the above-mentioned description of T. the following open problems were raised in [V.S. Afraimovich, S B. Hsu, Lectures on Chaotic Dynamical Systems, AMS International Press, 2003]. Is it true that, in general, h(T) = h(D)(T)= h(N)(T) = hl((1)),(l(2)) (T)? Here h(T) and hl((1),(2)) (T) (see Definitions 1.1 and 1.2) are, respectively, the spatial entropy of the system T and the spatial entropy of T with respect to the lines e(l) and E(2), and h(D)(T) and h(N)(T) are spatial entropy with respect to the Dirichlet and Neuman boundary conditions. If it is not true, then which parameters of the lines l((1)), i = 1.2, are responsible for the value of h(T)? What kind of bifurcations occurs if the lines l((1)) move? In this paper, we show that this is in general not always true. Among other things, we further give conditions for which the above problem holds true. (C) 2010 Elsevier Inc. All rights reserved.
Development of a Growth- Hormone- Conjugated Nanodiamond Complex for Cancer Therapy
(2014-05-01)
Chu, Hsueh-Liang
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Chen, Hung-Wei
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Tseng, Shin-Hua
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Hsu, Ming-Hua
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Ho, Li-Ping
It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a nanoblast and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy.
Ni(2+)-Enhanced Charge Transport via pi-pi Stacking Corridor in Metallic DNA
(2011-02-16)
Tseng, Shin-Hua
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JangJian, Peng-Chung
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Tsai, Chuan-Mei
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Cheng, Tsai-Mu
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Chu, Hsueh-Liang
The mechanism underlying DNA charge transport is intriguing. However, poor conductivity of DNA makes it difficult to detect DNA charge transport. Metallic DNA (M-DNA) has better conducting properties than native DNA. Ni(2+) may chelate in DNA and thus enhance DNA conductivity. On the basis of this finding, it is possible to reveal the mechanisms underlying DNA charge transport. The conductivity of various Ni-DNA species such as single-stranded, full complement, or mismatched sequence molecules was systematically tested with ultraviolet absorption and electrical or chemical methods. The results showed that the conductivity of single-stranded Ni-DNA (Ni-ssDNA) was similar to that of a native DNA duplex. Moreover, the resistance of Ni-DNA with a single basepair mismatch was significantly higher than that of fully complementary Ni-DNA duplexes. The resistance also increased exponentially as the number of mismatched basepairs increased linearly after the tunneling current behavior predicted by the Simmons model. In conclusion, the charges in Ni(2+)-doped DNA are transported through the Ni(2+)-mediated pi-pi stacking corridor. Furthermore, Ni-DNA acts as a conducting wire and exhibits a tunneling barrier when basepair mismatches occur. This property may be useful in detecting single basepair mismatches.
Ni2+-Enhanced Charge Transport via pi-pi Stacking Corridor in Metallic DNA
(2011-02-16)
Tseng, Shin-Hua
;
JangJian, Peng-Chung
;
Tsai, Chuan-Mei
;
Cheng, Tsai-Mu
;
Chu, Hsueh-Liang
The mechanism underlying DNA charge transport is intriguing. However, poor conductivity of DNA makes it difficult to detect DNA charge transport. Metallic DNA (M-DNA) has better conducting properties than native DNA. Ni2+ may chelate in DNA and thus enhance DNA conductivity. On the basis of this finding, it is possible to reveal the mechanisms underlying DNA charge transport. The conductivity of various Ni-DNA species such as single-stranded, full complement, or mismatched sequence molecules was systematically tested with ultraviolet absorption and electrical or chemical methods. The results showed that the conductivity of single-stranded Ni-DNA (Ni-ssDNA) was similar to that of a native DNA duplex. Moreover, the resistance of Ni-DNA with a single basepair mismatch was significantly higher than that of fully complementary Ni-DNA duplexes. The resistance also increased exponentially as the number of mismatched basepairs increased linearly after the tunneling current behavior predicted by the Simmons model. In conclusion, the charges in Ni2+-doped DNA are transported through the Ni2+-mediated pi-pi stacking corridor. Furthermore, Ni-DNA acts as a conducting wire and exhibits a tunneling barrier when basepair mismatches occur. This property may be useful in detecting single basepair mismatches.
Programmable Redox State of the Nickel Ion Chain in DNA
(2014-02-01)
Chu, Hsueh-Liang
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Chiu, Shao-Chien
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Sung, Ching-Feng
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Tseng, Wellen
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Chang, Yu-Chuan
DNA is a nanowire in nature which chelates Ni ions and forms a conducting chain in its base-pairs (Ni-DNA). Each Ni ion in Ni-DNA exhibits low (Ni2+) or high (Ni3+) oxidation state and can be switched sequentially by applying bias voltage with different polarities and writing times. The ratio of low. and high oxidation states of Ni ions in Ni-DNA represents a programmable multistate memory system with an added capacitive component, in which multistate information can be written, read, and erased. This study also indicates that the biomolecule-based self-organized nanostructure can be used as a template for nanodevice fabrication.
Stable Synchrony in Globally Coupled Integrate-and-Fire Oscillators
(2008)
Chang, Yu-Chuan
;
Juang, Jonq
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應用數學系
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Department of Applied Mathematics
A model of integrate-and-fire oscillators is studied. In the special case of identical oscillators, the model was first proposed and analyzed by Mirollo and Strogatz [SIAM J. Appl. Math., 50 (1990), pp. 1645-1662]. We assume, as in Mirollo and Strogatz's model, that each oscillator x(i) evolves according to a map f(i). Our main results are to demonstrate that the concavity structure of f(i) plays an important role in determining whether Peskin's second conjecture holds true. Specifically, the following statements are proved. First, the system of convex oscillators (i.e., f(i)'' < 0 for all i), in general, synchronizes when the oscillators are not quite identical. Second, the system of a certain class of concave oscillators (i.e., f(i)'' > 0 for all i) will not achieve synchrony for initial conditions in a set of positive measure when the oscillators are nearly identical. Third, the system of concave oscillators may achieve synchrony under certain sufficient conditions, provided that the oscillators are not quite nonidentical and that its concavity is small.
Synthesis of Apolipoprotein B Lipoparticles to Deliver Hydrophobic/Amphiphilic Materials
(2013-08-14)
Chu, Hsueh-Liang
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Cheng, Tsai-Mu
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Chen, Hung-Wei
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Chou, Fu-Hsuan
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Chang, Yu-Chuan
To develop a drug delivery system (DDS), it is critical to address challenging tasks such as the delivery of hydrophobic and amphiphilic compounds, cell uptake, and the metabolic fate of the drug delivery carrier. Low-density lipoprotein (LDL) has been acknowledged as the human serum transporter of natively abundant lipoparticles such as cholesterol, triacylglycerides, and lipids. Apolipoprotein B (apo B) is the only protein contained in LDL, and possesses a binding moiety for the LDL receptor that can be internalized and degraded naturally by the cell. Therefore, synthetic/reconstituting apoB lipoparticle (rABL) could be an excellent delivery carrier for hydrophobic or amphiphilic materials. Here, we synthesized rABL in vitro, using full-length apoB through a five-step solvent exchange method, and addressed its potential as a DDS. Our rABL exhibited good biocompatibility when evaluated with cytotoxicity and cell metabolic response assays, and was stable during storage in phosphate-buffered saline at 4 degrees C for several months. Furthermore, hydrophobic superparamagnetic iron oxide nanoparticles (SPIONPs) and the anticancer drug M4N (tetra-O-methyl nordihydroguaiaretic acid), used as an imaging enhancer and lipophilic drug model, respectively, were incorporated into the rABL, leading to the formation of SPIONPs- and M4N- containing rABL (SPIO@rABL and M4N@rABL, respectively). Fourier transform infrared spectroscopy suggested that rABL has a similar composition to that of LDL, and successfully incorporated SPIONPs or M4N. SPIO@rABL presented significant hepatic contrast enhancement in T-2-weighted magnetic resonance imaging in BALB/c mice, suggesting its potential application as a medical imaging contrast agent. M4N@rABL could reduce the viability of the cancer cell line A549. Interestingly, we developed solution-phase high-resolution transmission electron microscopy to observe both LDL and SPIO@rABL in the liquid state. In summary, our LDL-based DDS, rABL, has significant potential as a novel DDS for hydrophobic and amphiphilic materials, with good cell internalization properties and metabolicity.