Browsing by Author "Chao, Shu-Han"
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Item type:Item, Effect of Joint Shape Controlled by Thermocompression Bonding on the Reliability Performance of 60 mu m-pitch Solder Micro Bump Interconnections(2014-01-01) ;Huang, Yu-Wei ;Zhan, Chau-Jie ;Juang, Jing-Ye ;Lin Yu-MinHuang, Shin-YiThree dimensional integration circuits technology has received much attention recently since the demands of functionality and performance in microelectronic packaging for electronic products are rapidly increasing. For high-performance 3D chip stacking, high density interconnections are essential. In the current types of interconnects, solder micro bumps have been widely used and thermocompression bonding process are well adopted to form the connection between bumps. However, the prefect joint contour is difficult to obtain and control by such kind of bonding process in solder micro bump joints. For fine-pitch solder micro bump interconnections, the effect of joint shape on the reliability performances of the solder micro bump joints is not concluded yet till now and needs to be clarified. In this study, the effect of joint shape controlled by thermocompression bonding on the reliability performance of solder micro bump interconnections with a pitch of 60 mu m was discussed. The chip-to-chip test vehicle having more than 4000 solder micro bump interconnections with a bump pitch of 60 mu m was used in this study. A solder micro bump structure of Cu/SnAg having a thickness of 7 mu m/10 mu m was fabricated in both the silicon chip and substrate. To evaluate the effect of joint shape, four types of joint shape were controlled and made. The first type had a conventional shape of micro joint. Compared to the first one joint structure, the second type of joint structure showed the compressed shape. The third type of joint structure was the pillar-like micro joint while the fourth type of joint structure presented a neck shape having the highest joint height among all the joint structures tested. We used the fluxless thermocompression bonding process to form these four types of micro joints. After bonding process, the chip stack was assembled by capillary-type underfill. Reliability tests of temperature cycling test (TCT), high temperature storage (HTS) and electromigration test (EM) were selected to assess the effect of joint shape on the reliability properties of those four types of solder micro bump interconnections. The reliability results presented that all the types of joint structures could pass TCT of 1000 cycles and HTS of 1000 hours but high variation of daisy chain resistance more than 15% would happen in the neck-shape micro joint after TCT. For the neck-shape micro joint, the high variation of daisy chain resistance after TCT resulted from the cracking propagated along the interface of Cu UBM/Cu6Sn5 IMC and across the tin solder. The cracking situation was more serious as compared to the other three tested micro joints. The results of HTS revealed that resistance variation mainly depended on the micro structural evolution within micro joints tested. Electromigration test was conducted under the testing condition of 0.56 A/150 degrees C. A daisy chain structure was adopted. For both the pillar-shape and neck-shape micro joints, Cu UBM consumption and formation of large void were the major microstructure evolutions within the micro interconnections during EM testing. The conpressed-shape showed the longer electromigration lifetime among all the types of micro joints tested.Item type:Item, Failure mechanism of Cu/SnAg/Ni microbumps in three-dimensional integral circuits under electromigration(2014) ;Lin, Wan-Hsuan ;Chao, Shu-Han ;Zhan, Chau-Jie ;Huang, Yu-weiChen, ChihIn this study, we use the Cu/SnAgiNi/Cu joint with a thickness of 7 mu m/8 mu m/2 mu m /5 mu m and 7 mu m/16 mu m/2 mu m /5 mu m. The diameter of the solder joint is about 30 mu m and the UBM opening is 18 mu m in diameter with 60 pm pitches. In order to measure the resistance changes, it was fabricated which constitute four probes. By using this method we can measure the resistance changes in microbump excluding the resistance changes in the wiring trace to make it more sensitive to subtle microstructure changes. We investigated the mechanisms of electromigration in microbumps with different stages when resistance increased 20%, 50% and 100% of the initial resistance. Solder joints were stressed with 0.56 A on 150 degrees C hot plate. The average current density is 8 x 10(4) A/cm(2), calculated based on the UBM opening. We ground the samples with 1000, 2000, and 4000 sand paper and then polished them with 1 mu m, 0.3 mu m, and 0.05 mu m Al2O3. We observed their morphologies with SEM and measured their component with EDX. In the bump with electron flow upward, we observed that microbumps were transformed into Cu6Sn5 IMCs and Cu3Sn IMCs joints. In addition, voids were formed at the interface between nickel and solder. We found that both void formation and UBM dissolution were occurred. In the bump with electron flow downward; microbumps were transformed into IMC joints without void formation. To sum up, this study provides a better understanding on the relationship between the behavior of resistance curve and the morphology changes in microbumps.Item type:Item, Photocontrollable Probe Spatiotemporally Induces Neurotoxic Fibrillar Aggregates and Impairs Nucleocytoplasmic Trafficking(2017-07-01) ;He, Ruei-Yu ;Chao, Shu-Han ;Tsai, Yu-Ju ;Lee, Chi-ChangYu, Chu-YiThe abnormal assembly of misfolded proteins into neurotoxic aggregates is the hallmark associated with neurodegenerative diseases. Herein, we establish a photocontrollable platform to trigger amyloidogenesis to recapitulate the pathogenesis of amyotrophic lateral sclerosis (ALS) by applying a chemically engineered probe as a "switch" in live cells. This probe is composed of an amyloidogenic peptide from TDP-43, a photolabile linker, a polycationic sequence both to mask amyloidogenicity and for cell penetration, and a fluorophore for visualization. The photocontrollable probe can self-assemble into a spherical vesicle but rapidly develops massive nanofibrils with amyloid properties upon photo activation. The photoinduced in vitro fibrillization process is characterized by biophysical techniques. In cellular experiments, this cell-penetrable vesicle was retained in the cytoplasm, seeded the mislocalized endogenous TDP-43 into aggregates upon irradiation, and consequently initiated apoptosis. In addition, this photocontrollable vesicle interfered with nucleocytoplasmic protein transport and triggered cortical neuron degeneration. Our developed strategy provides in vitro and in vivo spatiotemporal control of neurotoxic fibrillar aggregate formation, which can be readily applied in the studies of protein misfolding, aggregation-induced protein mislocalization, and amyloid-induced pathogenesis in different diseases.