Browsing by Author "Chen, Arvin Y."

Now showing 1 - 2 of 2

Chemical Production from Methanol Using Natural and Synthetic Methylotrophs
(1970-01-01)
Chen, Arvin Y.
;
Lan, Ethan I.
;
生物科技學系
;
分子醫學與生物工程研究所
;
Department of Biological Science and Technology
Methanol as a chemical feedstock is becoming increasingly important as it is derived from natural gas and is a feasible end-product for captured carbon dioxide. Biological conversion of methanol through natural and synthetic methylotrophs increases the chemical repertoire and is an important direction for one carbon (C1) based chemical economy. Advances in the metabolic engineering and synthetic biology enable development of microbial cell factories for converting methanol into various platform chemicals. In this review, the current status of methanol utilizing microbial factory development is summarized. Also the development of synthetic methylotrophy and methanol-augmented bioproductions is discussed.
Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
(2020-04-01)
Ku, Jason T.
;
Chen, Arvin Y.
;
Lan, Ethan I.
;
生物科技學系
;
分子醫學與生物工程研究所
Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream products. In this review, we summarize the strategies that have been implemented for increasing acetyl-CoA flux and concentration, and discuss their effects. Furthermore, recent works have developed synthetic acetyl-CoA biosynthesis routes that achieve higher stoichiometric yield of acetyl-CoA from glycolytic substrates.