Browsing by Author "Chen, Chia-Yu"

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"Bounded & Nuanced": Designing Mobile Technology for Children and Parents
(2019-01-01)
Chen, Ying-Yu
;
Tseng, Yuan-Chi
;
Chen, Chia-Yu
;
Yuan, Tina
;
交大名義發表
In this workshop, we intend to bring scholars and practitioners of MobileHCI conference who are interested in designing technology use for children and their parents. Parents are concerned with technology addiction for their children but generally feel loss of control in the ubiquity of mobile devices. We believe mobile design community can contribute meaningful ideas in this space. The goal of this workshop is for participants to co-develop a shared vocabulary and framework for "designing bounded and nuanced technology" as a strategy to be deployed in conceiving and implementing mobile technologies for family use.
Does Who Matter? Studying the Impact of Relationship Characteristics on Receptivity to Mobile IM Messages
(2019-01-01)
Lee, Hao-Ping
;
Chen, Kuan-Yin
;
Lin, Chih-Heng
;
Chen, Chia-Yu
;
Chung, Yu-Lin
This study examines the characteristics of mobile instant-messaging users' relationships with their social contacts and the effects of both relationship and interruption context on four measures of receptivity: Attentiveness, Responsiveness, Interruptibility, and Opportuneness. Overall, interruption context overshadows relationship characteristics as predictors of all four of these facets of receptivity; this overshadowing was most acute for Interruptibility and Opportuneness, but existed for all factors. In addition, while Mobile Maintenance Expectation and Activity Engagement were negatively correlated with all receptivity measures, each such measure had its own set of predictors, highlighting the conceptual differences among the measures. Finally, delving more deeply into potential relationship effects, we found that a single, simple closeness question was as effective at predicting receptivity as the 12-item Unidimensional Relationship Closeness Scale.
Predicting Smartphone Users' General Responsiveness to IM Contacts Based on IM Behavior
(2019-01-01)
Lee, Hao-Ping
;
Chung, Yu-Lin
;
Dingier, Tilman
;
Chen, Chia-Yu
;
Lin, Chih-Heng
History of conversations through instant messaging (IM) contains abundant information about the communication patterns of the dyad, including conversation partners' mutual responsiveness to messages. We have, however, not seen many examinations of using such information in modeling mobile users' responsiveness in IM communication. In this paper, we present an in-the-wild study, in which we leverage participants' IM messaging logs to build models predicting their general responsiveness. Our models based on data from 33 IM user achieved an accuracy of up to 71% (AUROC). In particular, we show that 90-day IM-communication patterns, in general, outperformed their 14-day equivalent in our prediction models, indicating better coherence between long-term IM patterns with their general communication experience.
Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis
(2016-07-15)
Chen, Chia-Yu
;
Chan, Chieh-Hsiang
;
Chen, Chun-Ming
;
Tsai, Yin-Shuan
;
Tsai, Tsung-Yuan
The X-linked DEAD-box RNA helicase DDX3 (DDX3X) is a multifunctional protein that has been implicated in gene regulation, cell cycle control, apoptosis, and tumorigenesis. However, the precise physiological function of Ddx3x during development remains unknown. Here, we show that loss of Ddx3x results in an early post-implantation lethality in male mice. The size of the epiblast marked by Oct3/4 is dramatically reduced in embryonic day 6.5 (E6.5) Ddx3x(-)/Y embryos. Preferential paternal X chromosome inactivation (XCI) in extraembryonic tissues of Ddx3x heterozygous (Ddx3x(-/+)) female mice with a maternally inherited null allele leads to placental abnormalities and embryonic lethality during development. In the embryonic tissues, Ddx3x exhibits developmental-and tissue-specific differences in escape from XCI. Targeted Ddx3x ablation in the epiblast leads to widespread apoptosis and abnormal growth, which causes embryonic lethality in the Sox2-cre/+; Ddx3x(flox)/Y mutant around E11.5. The observation of significant increases in gamma H2AX and p-p53(Ser15) indicates DNA damage, which suggests that loss of Ddx3x leads to higher levels of genome damage. Significant upregulation of p21(WAF1/Cip1) and p15(Ink4b) results in cell cycle arrest and apoptosis in Ddx3x-deficient cells. These results have uncovered that mouse Ddx3x is essential for both embryo and extraembryonic development.
Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis
(2016-07-15)
Chen, Chia-Yu
;
Chan, Chieh-Hsiang
;
Chen, Chun-Ming
;
Tsai, Yin-Shuan
;
Tsai, Tsung-Yuan
The X-linked DEAD-box RNA helicase DDX3 (DDX3X) is a multifunctional protein that has been implicated in gene regulation, cell cycle control, apoptosis, and tumorigenesis. However, the precise physiological function of Ddx3x during development remains unknown. Here, we show that loss of Ddx3x results in an early post-implantation lethality in male mice. The size of the epiblast marked by Oct3/4 is dramatically reduced in embryonic day 6.5 (E6.5) Ddx3x(-)/Y embryos. Preferential paternal X chromosome inactivation (XCI) in extraembryonic tissues of Ddx3x heterozygous (Ddx3x(-/+)) female mice with a maternally inherited null allele leads to placental abnormalities and embryonic lethality during development. In the embryonic tissues, Ddx3x exhibits developmental-and tissue-specific differences in escape from XCI. Targeted Ddx3x ablation in the epiblast leads to widespread apoptosis and abnormal growth, which causes embryonic lethality in the Sox2-cre/+; Ddx3x(flox)/Y mutant around E11.5. The observation of significant increases in gamma H2AX and p-p53(Ser15) indicates DNA damage, which suggests that loss of Ddx3x leads to higher levels of genome damage. Significant upregulation of p21(WAF1/Cip1) and p15(Ink4b) results in cell cycle arrest and apoptosis in Ddx3x-deficient cells. These results have uncovered that mouse Ddx3x is essential for both embryo and extraembryonic development.