Browsing by Author "Chen, Chieh"

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Catalytic Behaviors in Modulating Enzymatic Activity through Different-sized Gold Nanoparticles
(2010)
Wu, Chung-Shu
;
Wu, Chia-Tien
;
Chen, Chieh
;
Huang, Chung-Chih
;
Yeh, Yu-Lin
We have demonstrated that gold nanoparticles (AuNPs) can effectively associate with enzyme through spontaneous adsorption to afford supramolecular complexes, resulting in a significant increase of its enzymatic activity. In this work, we embarked on a study of the interactions between the different-sized AuNPs and the substrate through quantifying the kinetic parameters (K(cat) and K(m)). The diversity of size allows us to probe the role of catalytic behaviors in modulating enzymatic activity.