Browsing by Author "Chen, Tsung-Yi"

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Development of an adaptive learning case recommendation approach for problem-based e-learning on mathematics teaching for students with mild disabilities
(2009-04-01)
Chu, Hui-Chuan
;
Chen, Tsung-Yi
;
Lin, Chia-Jou
;
Liao, Min-Ju
;
Chen, Yuh-Min
Most e-learning platforms offer theoretical knowledge content but not practical knowledge required for problem solving. This study proposed a problem-based e-learning (PBeL) model which incorporates the problem-based learning (PBL) theory, social constructivism, and situated learning theories to assist regular and special education teachers in effectively developing knowledge for mathematics teaching for students with mild disabilities. To support adaptive case-based learning in the proposed PBeL and to adequately address the real complexity and diversity of the learning problems of students' with mild disabilities, this research also developed an adaptive case recommendation approach which identifies the most suitable authentic learning cases based on the characteristics of learners (teachers), the strengths, weaknesses, and types of disabilities of their students, the teaching problems of various mathematical topics, and the teaching context in order to facilitate adaptive case-based learning in the context of problem-based e-learning for regular and special education teachers' knowledge development. Clustering and information retrieval techniques were used to construct the context and content maps for case-based reasoning with the capability of semantics identification. The adaptive recommendation approach not only enables the realization of adaptive PBeL, but also enhances teachers' practical knowledge and assists them to solve students' learning problems. (C) 2008 Elsevier Ltd. All rights reserved.
Learning case adaptation for problem-oriented e-learning on mathematics teaching for students with mild disabilities
(2011-03-01)
Chu, Hui-Chuan
;
Liao, Min-Ju
;
Chen, Tsung-Yi
;
Lin, Chia-Jou
;
Chen, Yuh-Min
Both problem-oriented learning and case-based learning are effective methods for practical knowledge development. However, an automatic development of learning cases for adaptive learning is still an open issue. To support adaptive case-based learning in a proposed problem-oriented e-learning (POeL) environment and to address the complexity and diversity of the learning problems of students with mild disabilities, this study presents a learning case adaptation framework to support problem-oriented e-learning. This framework provides mechanisms to search and match similar learning cases according to encountered teaching problems by information retrieval techniques and to develop an adaptive learning case by adaptation techniques. Adaptation techniques include a substitution technique, a removal technique, and a composition technique, and utilize cosine-measure and genetic algorithm. In this research, adaptive learning cases were developed for teaching students with mild disabilities so as to assist regular and special education teachers to develop practical knowledge of teaching more effectively. (C) 2010 Elsevier Ltd. All rights reserved,
Multilayer gold nanoparticle-assisted thermal desorption ambient mass spectrometry for the analysis of small organics
(2010)
Lin, Jia-Yi
;
Chen, Tsung-Yi
;
Chen, Jen-Yi
;
Chen, Yu-Chie
;
應用化學系
In this study, thermal desorption-based ambient mass spectrometry (TDAMS) for the analysis of small organics was explored. A layer-by-layer (LBL) self-assembled multilayer of a gold nanoparticle (AuNP)-based glass chip (Glass@AuNPs) with the absorption capacity in the near-infrared (NIR) region was used as the energy absorber and as the sample holder for sample deposition at ambient condition. An NIR laser diode (808 nm) was successfully employed as the thermal desorption source to liberate only small molecules from Glass@AuNPs chips. Followed by post-ionization, the resultant ions were monitored by an ion trap mass spectrometer. Post-ionization was assisted by a spray consisting of 50% deionized water-acetonitrile containing 0.1% acetic acid generated from a short tapered capillary by employing a high voltage (4 kV). Analytes with different polarities including small acids, amino acids, insecticides, and biodiesel samples such as ethyl esters can be directly analyzed using this approach. We demonstrated that this ambient mass spectrometric method was suitable for selectively analyzing small target organics directly from complex samples without any sample pretreatment.
Study of salt effects in ultrasonication-assisted spray ionization mass spectrometry
(2012-04-01)
Lo, Ta-Ju
;
Chen, Tsung-Yi
;
Chen, Yu-Chie
;
應用化學系
;
Department of Applied Chemistry
Ultrasonication-assisted spray ionization mass spectrometry for on-line monitoring of organic reactions
(2010)
Chen, Tsung-Yi
;
Chao, Chin-Sheng
;
Mong, Kwok-Kong Tony
;
Chen, Yu-Chie
;
應用化學系
A straightforward on-line monitoring of organic reactions by ultrasonication-assisted spray ionization mass spectrometry (UASI MS) is demonstrated in this work.
Ultrasonication-Assisted Spray Ionization Mass Spectrometry for the Analysis of Biomolecules in Solution
(2010-09-01)
Chen, Tsung-Yi
;
Lin, Jia-Yi
;
Chen, Jen-Yi
;
Chen, Yu-Chie
;
應用化學系
In this paper, we describe a novel technique-ultrasonication-assisted spray ionization (UASI) for the generation of singly charged and multiply charged gas-phase ions of biomolecules (e.g., amino acids, peptides, and proteins) from solution; this method employs a low-frequency ultrasonicator (ca. 40 kHz) in place of the high electric field required for electrospray ionization. When a capillary inlet is immersed into a sample solution within a vial subjected to ultrasonication, the solution is continually directed to the capillary outlet as a result of ultrasonication-assisted capillary action; an ultrasonic spray of the sample solution is emitted at the outlet of the tapered capillary, leading to the ready generation of gas-phase ions. Using an ion trap mass spectrometer, we found that singly charged amino acid and multiply charged peptides/proteins ions were generated through this single-step operation, which is both straightforward and extremely simple to perform. The setup is uncomplicated: only a low-frequency ultrasonicator and a tapered capillary are required to perform UASI. The mass spectra of the multiply charged peptides and proteins obtained from sample solutions subjected to UASI resemble those observed in ESI mass spectra. (J Am Soc Mass Spectrom 2010, 21, 1547-1553) (C) 2010 American Society for Mass Spectrometry