Browsing by Author "Chen, Y. -T."

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A new apparatus of infrared videopupillography for monitoring pupil size
(2013-01-01)
Ko, M. -L.
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Huang, T. -W.
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Chen, Y. -Y.
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Sone, B. -S.
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Huang, Y. -C.
Glaucoma was diagnosed or tracked by the intraocular pressure (IOP) generally because it is one of the physiology parameters that are associated with glaucoma. But measurement of IOP is not easy and consistence under different measure conditions. An infrared videopupillography is apparatus to monitor the pupil size in an attempt to bypass the direct IOP measurement. This paper propose an infrared videopupillography to monitoring the pupil size of different light stimulus in dark room. The portable infrared videopupillography contains a camera, a beam splitter, the visible-light LEDs for stimulating the eyes, and the infrared LEDs for lighting the eyes. It is lighter and smaller than the present product. It can modulate for different locations of different eyes, and can be mounted on any eyeglass frame. An analysis program of pupil size can evaluate the pupil diameter by image correlation. In our experiments, the eye diameter curves were not smooth and jagged. It caused by the light spots, lone eyelashes, and blink. In the future, we will improve the analysis program of pupil size and seek the approach to solve the LED light spots. And we hope this infrared videopupillography proposed in this paper can be a measuring platform to explore the relations between the different diseases and pupil response.
Correlation between Klebsiella pneumoniae carrying pLVPK-derived loci and abscess formation
(2010-06-01)
Tang, H. -L.
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Chiang, M. -K.
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Liou, W. -J.
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Chen, Y. -T.
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Peng, H. -L.
Klebsiella pneumoniae-caused liver abscess (KLA) is an emerging infectious disease. However, factors other than K1-specific loci that contribute to the pathogenesis of this disease have not been identified. pLVPK is a 219,385-bp plasmid of K. pneumoniae CG43, an invasive K2 strain associated with KLA. We aimed in this study to evaluate the involvement of pLVPK in K. pneumoniae virulence and its clinical significance in abscess formation. A pLVPK-cured CG43 was isolated and its virulence was examined in a mouse model. The prevalence of pLVPK-derived loci terW, iutA, rmpA, silS, and repA was investigated in 207 clinical isolates by screening with specific primers. Loss of pLVPK abolished the ability of K. pneumoniae to disseminate into extraintestinal sites and, consequently, attenuated abscess formation in mice. Primary K. pneumoniae abscess isolates (n = 94) were more likely to be terW (+)-iutA (+)-rmpA (+)-silS (+) than those related to non-abscess infections (n = 113) (62% vs. 27%; p < 0.0001). Logistic regression analysis indicated that the presence of the terW-rmpA-iutA-silS loci was a significant risk factor (odds ratio, 4.12; 95% confidence interval, 2.02-8.4; p < 0.0001) for abscess formation. pLVPK is a determinant for K. pneumoniae virulence and infection with strains carrying the pLVPK-derived terW-rmpA-iutA-silS loci may predispose patients to abscess formation.
GaN-based vertical-cavity surface emitting lasers with sub-milliamp threshold and small divergence angle
(2016-12-12)
Yeh, P. S.
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Chang, C. -C.
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Chen, Y. -T.
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Lin, D. -W.
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Liou, J. -S.
A GaN-based vertical-cavity surface emitting laser (VCSEL) structure featuring a silicon-diffusion-defined current blocking layer for lateral confinement is described. Sub-milliamp threshold currents were achieved for both 3- and 5-mu m-aperture VCSELs under continuous-wave operation at room temperature. The vertical cavity was defined by a top dielectric distributed Bragg reflector (DBR) and a bottom epitaxial DBR. The emission spectrum exhibited a single peak at 411.2 nm with a line-width of 0.4nm and a side mode suppression ratio of more than 10 dB before device packaging. The full-width-at-half-maximum divergence angle of the 3-mu m-aperture VCSEL was as small as approximately 5 degrees which is the lowest number reported. These results implied the 3-mu m-aperture VCSEL was in near single-mode operation. Published by AIP Publishing.
Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma
(1970-01-01)
Wang, Y. -J.
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Lin, E. -T.
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Chen, Y. -T.
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Chiu, P. -C.
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Lin, B. -S.
Background Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions. Objective We aimed to compare the efficacy and tolerance of the picosecond alexandrite laser with those of DLA and TCC in female Asian patients with melasma. Methods Twenty-nine patients were randomly assigned to group A1 (3 laser sessions at 4-week intervals), A2 (5 laser sessions at 4-week intervals) or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The Melasma Area, Severity Index (MASI) score and VISIA were assessed at baseline, week 12 and week 20. By week 20, the follow-up periods for groups A1 and A2 were 3 months and 1 month, respectively. Results Nine, 11 and 6 participants in groups A1, A2 and B completed the study, respectively. MASI scores were significantly improved in all 3 groups at weeks 12 and 20. In groups A1, A2 and B, the improvement rates at week 20 were 53%, 38% and 50%, respectively. VISIA analysis additionally revealed a significant improvement in spots, porphyria, pores and brown spots after 3 laser sessions (P < 0.05). Group A2 showed greater improvements than group A1 in terms of spots, wrinkles and pores; however, only red areas were significantly different (P < 0.001). All side-effects in the 3 groups were transient and gradually subsided after 1-3 months. Conclusion Picosecond alexandrite laser treatment using DLA showed comparable efficacy with TCC for the treatment of melasma. Improvements in texture, spots, wrinkles and pores were observed in the laser groups. Patients with melasma lesions that exhibit telangiectasia may benefit from additional laser treatment sessions.
Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma
(2020-03-01)
Wang, Y. -J.
;
Lin, E. -T.
;
Chen, Y. -T.
;
Chiu, P. -C.
;
Lin, B. -S.
BackgroundRecent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been identified to be effective for improving photoaging conditions. ObjectiveWe aimed to compare the efficacy and tolerance of the picosecond alexandrite laser with those of DLA and TCC in female Asian patients with melasma. MethodsTwenty-nine patients were randomly assigned to group A1 (3 laser sessions at 4-week intervals), A2 (5 laser sessions at 4-week intervals) or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The Melasma Area, Severity Index (MASI) score and VISIA were assessed at baseline, week 12 and week 20. By week 20, the follow-up periods for groups A1 and A2 were 3 months and 1 month, respectively. ResultsNine, 11 and 6 participants in groups A1, A2 and B completed the study, respectively. MASI scores were significantly improved in all 3 groups at weeks 12 and 20. In groups A1, A2 and B, the improvement rates at week 20 were 53%, 38% and 50%, respectively. VISIA((R)) analysis additionally revealed a significant improvement in spots, porphyria, pores and brown spots after 3 laser sessions (P < 0.05). Group A2 showed greater improvements than group A1 in terms of spots, wrinkles and pores; however, only red areas were significantly different (P < 0.001). All side-effects in the 3 groups were transient and gradually subsided after 1-3 months. ConclusionPicosecond alexandrite laser treatment using DLA showed comparable efficacy with TCC for the treatment of melasma. Improvements in texture, spots, wrinkles and pores were observed in the laser groups. Patients with melasma lesions that exhibit telangiectasia may benefit from additional laser treatment sessions.