Browsing by Author "Chen, Yi-Yu"

Now showing 1 - 4 of 4

Higher NAFLD fibrosis score is associated with impaired eGFR
(2020-01-01)
Hsieh, Meng-Hsuan
;
Wu, Kuan-Ta
;
Chen, Yi-Yu
;
Yang, Jeng-Fu
;
Lin, Wen-Yi
Background/Purpose: Chronic kidney disease (CKD) has become a worldwide health problem, leading to high morbidity and mortality, and non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for CKD. The aim of this study was to explore the relationship between NAFLD fibrosis score (NFS) and the estimated glomerular filtration rate (eGFR), and identify possible risk factors related to the NFS among Taiwanese subjects. Methods: Subjects were enrolled from the database of the Department of Preventive Medicine of Kaohsiung Municipal Hsiao-Kang Hospital. The eGFR was calculated according to the Taiwanese Modification of Diet in Renal Disease (TMDRD) equation, and the NFS was employed to evaluate the fibrotic level. Results: In total, 11,376 subjects were enrolled in this study, with a mean age of 52.0 +/- 6.81 years, including 4529 (39.8%) males. A fasting sugar level >= 100 mg/dL (OR = 1.70, 95% CI = 1.52-1.87) and an abnormal waist circumference (OR = 1.81, 95% CI = 1.65-1.99) were significant factors associated with NFS (p < 0.05). Trends of a decreasing TMDRD score and an increasing NFS with increasing age were noted (p < 0.05). The NFS was significantly negatively correlated with the TMDRD score (standard coefficients: -0.067, p < 0.001). Conclusion: A higher NFS is associated with an impaired eGFR in Taiwanese subjects. Controlling risk factors, especially fasting sugar level and waist circumference, may be useful in preventing NFS deterioration, which is negatively correlated with the eGFR. Copyright (C) 2019, Formosan Medical Association. Published by Elsevier Taiwan LLC.
Metallo-homopolymer and metallo-copolymers containing light-emitting poly (fluorene/ethynylene/(terpyridyl)zinc (II)) backbones and 1,3,4-oxadiazole (OXD) pendants
(2007-08-24)
Chen, Yi-Yu
;
Lin, Hong-Cheu
;
材料科學與工程學系
;
Department of Materials Science and Engineering
A series of novel metallo-polymers containing light-emitting poly(fluorene/ethynylene/(terpyridyl)zinc(II)) backbones and electrontransporting 1,3,4-oxadiazole (OXD) pendants (attached to the C-9 position of fluorene by long alkyl spacers) were synthesized by self-assembled reactions. The integrated ratios of H-1 NMR spectra reveal a facile result to distinguish the well-defined main-chain metallo-polymeric structures which were constructed by different monomer ligand systems (i.e. single, double, and triple monomer ligands with various pendants). Furthermore, UV-vis and photoluminescence (PL) spectral fitration experiments were carried out to verify the metallo-polymeric structures by varying the molar ratios of zinc(II) ions to monomers. As a result, the enhancement of thermal stability (T-d) and quantum yields were introduced by the metallo-polymerization, and their physical properties were mainly affected by the nature of the pendants. The photophysical properties of these metallo-polymers exhibited blue PL emissions (around 418 nm) with quantum yields of 34-53% (in DMF). In contrast to metallo-polymers containing alkyl pendants, the quantum yields were greatly enhanced by introducing 1,3,4-OXD pendants but reduced by carbazole (CAZ) pendants. Moreover, electrolumineseent (EL) devices with these light-emitting metallo-polymers as emitters showed green EL emissions (around 550 nm) with turn-on voltages of 6.0-6.5 V, maximum efficiencies of 1.05-1.35 cd A(-1) (at 100 mA/cm(-2)), and maximum luminances of 2313-3550 cd/m(2) (around 15 V), respectively. (c) 2007 Elsevier Ltd. All rights reserved.
Novel self-assembled metallo-homopolymers and metallo-alt-copolymer containing terpyridyl zinc(II) moieties
(2006-12-12)
Chen, Yi-Yu
;
Tao, Yu-Tai
;
Lin, Hong-Cheu
;
材料科學與工程學系
;
Department of Materials Science and Engineering
A series of novel terpyridyl Zn(II)-based metallo-polymers, including metallo-homopolymers and metallo-alt-copolymer, containing carbazole pendants attached to the C-9 position of fluorene by long alkyl spacers were constructed by self-assembled reaction. The integrated ratios of H-1 NMR reveal a facile result to distinguish the differences between metallo-homopolymers and copolymers. To further investigate these polymers, UV-vis and PL spectral titration experiments were also carried out by varying the molar ratios of zinc(II) ions to monomers. The photophysical properties of these polymers exhibited blue PL emissions (around 420 nm) with quantum yields of 11-23% (in DMF) and the PL results revealed that the formation of excimers were suppressed by the incorporation of carbazole pendant groups. In addition, the EL results showed green EL emissions ( around 550 nm) with turn-on voltages of 6.0-6.5 V, maximum efficiencies of 0.85-1.1 cd A(-1) (at 100 mA cm(-2)), and maximum luminances of 1704-2819 cd/m(2) (around 15 V), correspondingly.
Synthesis and characterization of light-emitting main-chain metallo-polymers containing bis-terpyridyl ligands with various lateral substituents
(2007-08-01)
Chen, Yi-Yu
;
Lin, Hong-Cheu
;
材料科學與工程學系
;
Department of Materials Science and Engineering
A series of conjugated monomers (5a-5d) with various lateral substituents were symmetrically synthesized by the Sonogashira coupling reaction, in which central aromatic units (i.e. 9,9-dipropylfluorenes) were linked to 2,2':6',2'-terpyridyl (tpy) units via phenylene/ethynylene fragments. These light-emitting monomers were further reacted with zinc(II) ions and subsequently anion exchanged to produce supramolecular main-chain metallo-polymers (6a-6d). The formation of polymers 6a-6d was confirmed by the increased viscosities (up to 1.5-1.83 times) relative to those of their analogous monomers. The results of H-1 NMR titration and UV-Vis spectral titration revealed a detailed complexation process of metallo-polymers by varying the molar ratios of zinc(II) ions to monomers. After coordination with zinc(II) ions, the luminescent and thermal properties of the polymers were enhanced by the formation of metallo-supramolecular structures in contrast to their monomer counterparts. PLED devices employing these metallo-polymers as emitters gave yellow to orange electroluminescence (EL) emissions with turn-on voltages around 6 V The maximum power efficiency, external quantum yield, and brightness of the PLED device containing polymer 6c were 0.33 cd A(-1) (at 14 V), 1.02%, and 931 cd m(-2) (at 14 V), respectively. (c) 2007 Wiley Periodicals, Inc.