Browsing by Author "Chen, Ying-Ho"

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Selective C(8)-H Activation of Imidazopyridines Mediated by Cooperative Nickel-Aluminum Catalysis
(2016-09-01)
Liu, Cheng-Yuan
;
Chen, Ying-Ho
;
Chen, Chih-Hao
;
Yu, Ming-Shiuan
;
Tsai, Fu-Yu
A catalytic paradigm is described featuring a synergistic interaction between nickel, aluminum and different ligands to impart a rather remote C-H alkenylation of imidazo[1,5-a] pyridines at the C-8 position without the necessity of installing a directing group. The scope of the direct C-H activation reactions of various 5-aryl- and 3-arylimidazopyridines is established using different sterically hindered alkynes.