Browsing by Author "Chen, Yu-Tsung"

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A RANDOMIZED CONTROLLED TRIAL OF PICOSECOND ALEXANDRITE LASER WITH A DIFFRACTIVE LENS ARRAY COMPARED TO TRIPLE COMBINATION CREAM FOR MELASMA IN ASIANS
(2019-02-01)
Chang, Chang Cheng
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Wang, Yen Jen
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Lin, Erh Ti E.
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Chen, Yu-Tsung
;
Lin, Bor-Shyh
Combined vitamin C sonophoresis and neodymium-doped yttrium aluminum garnet (NdYAG) laser for facial hyperpigmentation: An outcome observation study in Asian patients
(2016-09-10)
Chen, Yu-Tsung
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Chang, Chang-Cheng
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Hsu, Cherng-Ru
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Shen, Jen-Hsiang
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Shih, Chao-Jen
Background: The neodymium-doped yttrium aluminum garnet (NdYAG) laser therapy has been a popular technique for facial rejuvenation but certain adverse effects like post-inflammatory hyperpigmentation are issues of concern to Asian patients. Aims: To assess the outcome following combined treatment with vitamin C sonophoresis and NdYAG laser, in selected cases of facial hyperpigmentation. Methods: Twenty three women with dyschromia or melasma who had undergone five sessions of Q-switched NdYAG laser therapy followed by transdermal delivery of vitamin C via sonophoresis were selected after a retrospective review of case records. The objective and subjective clinical outcomes and the side effects, including erythema, scaling, pruritus, dryness and post-inflammatory hyperpigmentation were evaluated. Results: In both objective or subjective outcomes, 91.3% (21/23) of the patients showed an excellent or better outcome, while 8.7% (2/23) showed no change. A majority of the patients (73.9%, 17/23) experienced no post-inflammatory hyperpigmentation or had slight post-inflammatory hyperpigmentation which quickly resolved within 1 week. Only one (4.3%) patient had extreme post-inflammatory hyperpigmentation which lasted for over a month. Limitations: This was a retrospective study without a control group; a comparative study with a control group (patients treated with the laser alone, without vitamin C sonopheresis) is needed to determine the difference in the outcome. Conclusion: The use of vitamin C sonophoresis along with NdYAG laser may reduce the incidence of adverse effects in Asian patients. Patients experienced obvious improvement in hyperpigmentation and had lower chances of experiencing extreme or severe post-inflammatory hyperpigmentation.
Efficacy and Safety Evaluation of Picosecond Alexandrite Laser with a Diffractive Lens Array for Treatment of Melasma in Asian Patients by VISIA Imaging System
(2019-09-01)
Chen, Yu-Tsung
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Lin, Erh-Ti
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Chang, Chang-Cheng
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Lin, Bor-Shyh
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Chiang, Hsiu-Mei
Objective: To evaluate the efficacy and safety of picosecond (ps) 755-nm alexandrite laser with a diffractive lens array (DLA) generating laser-induced optical breakdown, which may be beneficial for melasma treatment. Background: Melasma is notorious for difficult to treat with any modality setting. Recently, picosecond alexandrite laser with DLA seems promising for dealing with it without intolerable complications. Methods: Twenty (N = 20) Asian female melasma patients with Fitzpatrick skin type IV were recruited for 3 treatment sessions of picosecond 755-nm alexandrite laser with DLA at a 4- to 6-week interval. The pulse duration was 750 ps. An 8-mm spot size and the fluence of 0.4 J/cm(2) was used over the target area with 2 passes per treatment area and around 2000-2500 passes in total. The repetition rate was 10 Hz. Melasma Area and Severity Index (MASI) score and VISIA (R) imaging system analysis were utilized for evaluation before treatment and 4 weeks after the completion of the third treatment session. The clinical improvement and adverse events were assessed by the physicians and patients, respectively. Results: The median age of the patients was 45 years (from 27 to 55 years). In the physicians' evaluation, 40% (n = 8) of patients showed good improvement and 40% (n = 8) of patients showed moderate improvement. The mean MASI score before and after laser therapy showed significant improvement from 9.0 +/- 4.8 to 6.5 +/- 3.7 (p < 0.001). VISIA analysis of the forehead presented significant improvement in spots (p = 0.007) and porphyrins (p = 0.032). Some patients experienced erythema (25%), pruritus (20%), and scaling (20%) but subsided within few days of using emollients and sunscreen. Only 5% (n = 1) of patients developed mild postinflammatory hyperpigmentation, which also subsided in 3 weeks. Conclusions: Three sessions of picosecond 755-nm alexandrite laser with a DLA were effective for melasma treatment in Asian patients with minimal side effects.
EVALUATION OF THE SAFETY AND EFFICACY OF THE PICOSECOND ALEXANDRITE LASER WITH SPECIALIZED FOCUS LENS ARRAY FOR TREATMENT OF THE MELASMA IN ASIAN PATIENTS
(2018-04-01)
Chang, Cheng Chang
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Chen, Yu-Tsung
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Chiang, Hsiu-Mei
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Lin, Bor-Shyh
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影像與生醫光電研究所
Using a Low Fluence Q-Switched 532/1064-nm Nd:YAG Laser for Facial Skin Depigmentation in Asian Patients Outcome and Complication Profile Analysis
(2016-08)
Shen, Jen-Hsiang
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Chang, Chang-Cheng
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Chen, Yu-Tsung
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Hsih, Chao-Jen
;
Huang, Hsin
Background and Objectives: Low fluence Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers are widely applied for facial depigmentation. Nonetheless, few reports analyze the general outcome, complications, of single and combined therapy of 532/1064-nm Nd: YAG lasers in Asian patients with Fitzpatrick type IV skin. Study Design/Materials and Methods: We retrospectively reviewed all consecutive patients who completed 5 consecutive sessions at 1-month intervals of treatment with 1064-nm (spot size: 5-7 mm, 1.5-2.0 J/cm(2)) or combined with 532-nm (spot size, 2-3 mm; 0.5-1.5 J/cm(2)) Nd: YAG laser (Laseroptek, Korea) from October 2011 to March 2013. The patients, laser surgeon, and 3 blinded reviewers assessed the outcomes and complications. Improvement was graded as follows: 1, 0%-25%; 2, 26%-50%; 3, 51%-75%; 4, 76-90%; and 5, greater than 90%. Postinflammatory hyperpigmentation (PIH) was documented according to the severity (1, slight; 2, moderate; 3, severe; and 4, extreme). Other post-laser side effects were also documented (eg, scaling, dryness, erythema, and pruritus). Results: Four male patients and 37 female patients were included with a mean age of 38.5 years (SD, 10.1 years). There were no significant differences on patients\', surgeon\'s, or blinded reviewers\' improvement gradings. (4.11 +/- 0.62 vs 4.30 +/- 0.46, P = 0.54; 3.88 +/- 0.66 vs 3.89 +/- 0.31, P = 0.50; 3.30 +/- 0.69 vs 3.74 +/- 0.38, P = 0.34). Transient minor side effect occurred as follows: erythema in 9 (22%), pruritus in 7 (17%), dryness in 6 (15%), and scaling in 6 (15%). There was no risk difference in these side effects between groups. The PIH scores were slight in 10 patients (4 in single and 6 in combined), severe in 4 (3 in single and 1 in combined), and extreme in 1 (single therapy). The PIH incidence also did not differ (33.3%, 35.3%; P = 0.58). Conclusions: We reported satisfactory outcomes after low-fluence Q-switched sole 1064-nmor combined 532/1064-nm therapy. The outcome and complication profiles did not differ between the groups. The PIH incidence was not low, but usually transient. The incidence of severe or extreme PIH was rare.
WIRELESS NEAR-INFRARED SPECTROSCOPE TO REAL-TIME QUANTITATIVELY ASSESS DORSAL FOOT PERIPHERAL CIRCULATION IN PATIENTS WITH DIABETES FOOT ULCER: A PILOT STUDY
(2016-03)
Lin, Yen Pin
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Chang, Chang Cheng
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Su, Zeng Wei
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Chang, Yin-Shuo
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Lin, Borshyh