Browsing by Author "Cheng, Yi-Lin"

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A Conductive Chemistry Online Argumentation Courseware with Website Exploring Support
(2015)
Huang, Kai-Yi
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Cheng, Yi-Lin
;
She, Hsiao-Ching
;
Lin, Yu-Ren
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教育研究所
There is considerable disagreement among researchers about chemistry learning approach. Some have been said to demonstrate an individual advantage, some a social advantage. While there is a great deal of general literature on this field, however, the specific web-based conductive learning is relatively unexplored. We proposed a Chemistry Online Argumentation Courseware (COAC) for enhancing 10th grade students\' learning with website exploring conductive components where senior high school students can easily navigate the embedded website links and create effective scientific arguments. The purpose of this paper is to report on an investigation of learners\' online argumentation activity. Answers were sought to the question: how does the website exploring strategy influence students\' argumentation performance on our conductive COAC. Qualitative results suggested that both Individual and Social group learners had significant improvements in their argumentation ability with the support of website exploring. This study further suggested that the benefit of website exploring argumentation-strategies instruction to the Individual group learners in the chemistry course; they improved fast enough to attain the same progress as the collaborative learners regarding argumentation-based learning. The findings of this study could serve as some general principles for teachers who would like to improve students\' website learning strategy use.
Interplay between Structure and Fluidity of Model Lipid Membranes under Oxidative Attack
(2010-12-02)
Tai, Wan-Yu
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Yang, Yi-Cyun
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Lin, Hui-Jen
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Huang, Chin-Ping
;
Cheng, Yi-Lin
A proper regula:ion of membrane fluidity is critical for cellular activities such as communication between cells, mitosis, an :I endocytosis. Unsaturated lipids, a main component of biological membranes, are particularly susceptible to oxidative attack of reactive oxygen species. The oxidation of lipids can produce structural derangement of membranes and eventually alter the membrane fluidity. We have applied fluorescence correlation spectroscopy (FCS) and Raman spectroscopy to investigate the fluidity and structure of model membranes subject to oxidative attack. Hydrogen peroxide has little effect on the lateral fluidity of membranes. whereas hydroxyl radical causes a significantly increased fluidity. The latter is rationalized with the cleavage of the acyl chains of lipids caused by hydroxyl radical; this interpretation is founded on the diminished intensities of lines in Raman spectra associated with -CH(2) and C = C moieties in lipids and supported by mass-spectral measurements. The same approach provides a mechanistic account of the inhibitory capability of vitamins C and E against ate increased membrane fluidity resulting from an oxidative attack. Membranes with much cholesterol exhibit a novel resistance against altered membrane fluidity induced with oxidative attack; this finding has biological implications. Our approach combining FCS and Raman measurements reveals the interplay between the structure and fluidity of membranes and provides insight into the pathophysiology of cellular oxidative injury.