Browsing by Author "Chiou, Jin Chern"

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Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin
(2012)
Chen, Yu-Shiun
;
Hung, Yao-Ching
;
Hong, Meng-Yeng
;
Onischuk, Andrei Aleksandrovich
;
Chiou, Jin Chern
"Nanoparticles are unfamiliar to researchers in toxicology. Toxicity may be generated simply due to the reduction in size. Compounds that prevent or cure toxic materials may not work on nanoparticles. Furthermore, as there are more and more applications of nanoparticles in drug delivery and in vivo imaging, controlling the transport and toxicity will be primary concerns for medical application of nanoparticles. Gold nanoparticles (GNPs) if injected intraperitoneally into mice can enter hippocampus and induce cognitive impairment. GNPs caused a global imbalance of monoamine levels, specifically affecting the dopaminergic and serotonergic neurons. Pretreatment of tea melanin significantly prevented the deposition of GNPs in mouse brains, especially in the hippocampus. Pretreatment of melanin completely alleviated GNP-induced impairment of cognition. Pre-administration of melanin stably maintained monoamines at normal profiles. Melanin completely prevented the invasion of GNPs into the Cornu Ammonis region of the hippocampus shown by coherent anti-Stoke Raman scattering microscopy. Here we show that the administration of tea melanin prevented the accumulation of Au in brain, the imbalance of monoamines, and the impairment of cognition in mice. The current study provides a therapeutic approach to toxicity of nanoparticles and a novel strategy to control the transport of GNP in mouse brain."
Fabrication and Verification for the Small-Form-Factor Holographic Optical Pickup
(2011-01-01)
Hou, Kuan Chou
;
Chou, Po Chien
;
Cheng, Stone
;
Lin, Yue Jheng
;
Chiu, Yi
In this investigation, a small-form-factor (SFF) pickup head with a holographic optical element (HOE) is fabricated. The system employs a finite-conjugate object lens to focus a light beam. A holographic optical element is used to simplify the optical configuration. It provides a better means of alignment of fabrication and reduces the size of system relative to reflective light route. Micro prisms are fastened with HOE and a silicon substrate, laser diode and photodiode are integrated into the optical system. The pickup head system based on discrete components and a flip chip bonder with highly accurate alignment was to integrate it. The micro holographic optical pickup head is fabricated and tested. Experimental results including the spot diameter and the focusing error signal (FES), demonstrate that the optical system is a feasible. (C) 2011 The Japan Society of Applied Physics