Browsing by Author "Cho, Ching-Chang"

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Diabetic Nephropathy Accelerated by Imbalance of Renal Renin-Angiotensin System Components in db/db Mice with High Fat Diet
(2017-04-01)
Wang, Guan-Hua
;
Cho, Ching-Chang
;
Lin, Chung-I
;
Wu, Hsi-Tien
;
Lin, Chih-Sheng
Disorder of Renin-Angiotensin System Promoting the Acute Pulmonary Inflammation by Particulate Matter 2.5 (PM2.5) Exposure
(2017-04-01)
Lin, Chung-I
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Wang, Guan-Hua
;
Cho, Ching-Chang
;
Wu, Hsi Tien
;
Hsieh, Wen-Yeh
Imbalanced plasma ACE and ACE2 level in the uremic patients with cardiovascular diseases and its change during a single hemodialysis session
(2017-11-20)
Yang, Chung-Wei
;
Lu, Li-Che
;
Chang, Chia-Chu
;
Cho, Ching-Chang
;
Hsieh, Wen-Yeh
Background: The renin-angiotensin system (RAS) has significant influences on heart and renal disease progression. Angiotensin converting enzyme (ACE) and angiotensin converting enzyme II (ACE2) are major peptidases of RAS components and play counteracting functions through angiotensin II (Ang II)/ATIR and angiotensin-(1-7) (Ang-(1-7))/Mas axis, respectively. Methods: There were 360 uremic patients on regular hemodialysis (HD) treatment (inclusive of 119 HD patients with cardiovascular diseases (CVD) and 241 HD patients without CVD and 50 healthy subjects were enrolled in this study. Plasma ACE, ACE2, Ang II and Ang-(1-7) levels of the HD patients were determined. Results: We compared pre-HD levels of plasma ACE, ACE2, Ang II and Ang-(1-7) in the HD patients with and without CVD to those of the controls. The HD patients, particularly those with CVD, showed a significant increase in the levels of ACE and Ang II, whereas ACE2 and Ang-(1-7) levels were lower than those in the healthy controls. Therefore, imbalanced ACE/ACE2 was observed in the HD patients with CVD. In the course of a single HD session, the plasma ACE, ACE/ACE2 and Ang II levels in the HD patients with CVD were increased from pre-HD to post-HD. On the contrary, ACE2 levels were decreased after the HD session. These changes were not detected in the HD patients without CVD. Conclusions: Pathogenically imbalanced circulating ACE/ACE2 was detected in the HD patients, particularly those with CVD. HD session could increase ACE/Ang II/AT1R axis and decrease ACE2/Ang-(1-7)/Mas axis activity in the circulation of HD patients with CVD.
Imbalanced Plasma ACE and ACE2 ratio in the Uremic Patients with Cardiovascular Diseases and Its Change during a Single Hemodialysis Session
(2017-04-01)
Cho, Ching-Chang
;
Lu, Li-Che
;
Chang, Chia-Chu
;
Lin, Chung-I
;
Wang, Guan-Hua
In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression
(2018-07-01)
Cho, Ching-Chang
;
Hsieh, Wen-Yeh
;
Tsai, Chin-Hung
;
Chen, Cheng-Yi
;
Chang, Hui-Fang
Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM2.5), and the components may also have different effects on people. The pathogenesis of PM2.5 in several diseases remains to be clarified. There is a long history of epidemiological research on PM2.5 in several diseases. Numerous studies show that PM2.5 can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM2.5 that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM2.5 in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM2.5-induced disease.