Browsing by Author "Chou, Chu-En"

Now showing 1 - 1 of 1

Formal synthesis of schulzeines B and C: A new route to Gurjar's lactams
(1970-01-01)
Chou, Chu-En
;
Chen, Yi-An
;
Lin, Yi-Ching
;
Kao, Shih-Chieh
;
Chang, Chieh-Yu
Described is a formal synthesis of racemic schulzeines B and C that intercepts intermediates developed by Gurjar and co-workers. The synthetic sequence features an annulative coupling of a ketimine and acrylic acid enabling the construction of the benzoquinolizidine nucleus in a highly convergent manner. We also examined a continuous-flow version of the thermal aza-annulation, which proved less practical as compared to the batch processes.