Browsing by Author "Chou, Shih-Ching"

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Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment
(2015-01-01)
Huang, Lin-Chiang Sherlock
;
Chuang, Hong
;
Kapoor, Mohit
;
Hsieh, Cheng-Ying
;
Chou, Shih-Ching
In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistantMES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.
Simple and highly efficient direct thiolation of the surface of carbon nanotubes
(2014)
Hsu, Ming-Hua
;
Chuang, Hong
;
Cheng, Fong-Yu
;
Huang, Ying-Pei
;
Han, Chien-Chung
We established a highly efficient and simple method to directly functionalize the surface of carbon nanotubes (CNTs) with thiol groups (-SH). The -SH groups on the surface of the CNTs were characterized using Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), elemental analysis (EA), and transmission electron microscopy (TEM). The TEM indicated that gold nanoparticles (Au NPs) or other metals can be attached to thiolated CNTs (CNT-SHs) through thiol-metal bonding. Hence, the proposed approach can be used for developing self-assembled materials, sensors, catalysts, and CNT nanodevices.