Browsing by Author "Chuang, Ming-Lung"

Now showing 1 - 5 of 5

Diffuse Optical Multipatch Technique for Tissue Oxygenation Monitoring: Clinical Study in Intensive Care Unit
(2012-01-01)
Wang, Chun-Yang
;
Chuang, Ming-Lung
;
Liang, Shinn-Jye
;
Tsai, Jui-che
;
Chuang, Ching-Cheng
Diffuse optical multipatch technique is used to assess spatial variations in absorption and scattering in biological tissue, by monitoring changes in the concentration of oxyhemoglobin and deoxyhemoglobin. In our preliminary study, the temporal tracings of tissue oxygenation are measured using diffuse optical multipatch measurement and a venous occlusion test, employing normal subjects and ICU patients suffering from sepsis and heart failure. In experiments, obvious differences in tissue oxygenation signals were observed among all three groups. This paper discusses the physiological relevance of tissue oxygenation with respect to disease.
Hemodynamic analysis of patients in intensive care unit based on diffuse optical spectroscopic imaging system
(2010)
Hsieh, Yao-Sheng
;
Wang, Chun-Yang
;
Ling, Yo-Wei
;
Chuang, Ming-Lung
;
Chuang, Ching-Cheng
Diffuse optical spectroscopic imaging (DOSI) is a technique to assess the spatial variation in absorption and scattering properties of the biological tissues and provides the monitoring of changes in concentrations of oxy-hemoglobin and deoxy-hemoglobin. In our preliminary study, the temporal tracings of hemodynamic oxygenation are measured with DOSI and venous occlusion test (VOT) from normal subjects, patients with heart failure and patients with sepsis in intensive care unit (ICU). In experiments, the obvious differences of hemodynamic signals can be observed among the three groups. The physiological relevance of VOT hemodynamics with respect to diseases is also discussed in this paper.
Muscle oxygenation dynamics in response to electrical stimulation as measured with near-infrared spectroscopy: A pilot study
(2019-03-01)
Huang, Yi-Hua
;
Chuang, Ming-Lung
;
Wang, Pay-Zen
;
Chen, Yueh-Chi
;
Chen, Chung-Ming
Neuromuscular electrical stimulation (NMES) is used for preventing muscle atrophy and improving muscle siren in patients and healthy people. However, the current intensity of NMES is usually set at a level that causes the stimulated muscles to contract. This typically causes pain. Quantifying the instantaneous changes in muscle microcirculation and metabolism during NMES before muscle contraction occurs is crucial, because it enables the current intensity to be optimally tuned, thereby reducing the NMES-induced muscle pain and fatigue. We applied near-infrared spectroscopy (MRS) to measure instantaneous tissue oxygenation and deoxygenation changes in 43 healthy young adults during NMES at 10, 15, 20, 25, 30, and 35 mA. Having been stabilized at the NIRS signal baseline, the tissue oxygenation and total hemoglobin concentration increased immediately after stimulation in a dose-dependent manner (P < 0.05) until stimulation was stopped at the level causing muscle contraction without pain. Tissue deoxygenation appeared relatively unchanged during NMES. We conclude that NIRS can be used to determine the optimal NMES current intensity by monitoring oxygenation changes.
Oxygenation dynamics of sepsis patients undergoing far-infrared intervention based on near-infrared spectroscopy
(2017-03-01)
Chuang, Kuei-Hung
;
Chuang, Ming-Lung
;
Sia, Sung-kien
;
Sun, Chia-Wei
;
光電工程學系
Near-infrared spectroscopy (NIRS; continuous wave type) is a noninvasive tool for detecting the relative change of oxyhemoglobin and deoxyhemoglobin. To make this change, intervention methods must be applied. This study determined the hemodynamics of 44 healthy participants and 35 patients with sepsis during exposure to FIR as a novel physical intervention approach. Local microcirculation of their brachioradialis was monitored during exposure and recovery through NIRS. The variations in blood flow and microvascular reaction were determined by conducting paired and unpaired t tests. The oxyhemoglobin levels of the healthy participants increased continuously, even during recovery. In contrast to expextations, the oxyhemoglobin levels of the patients plateaued after only 5 min of FIR illumination. The proposed method has potential applications for ensuring efficient treatment and facilitating doctors in diagnosing the functions of vessels in intensive care units. Mapping diagrams of HbO(2) in healthy males and males with sepsis illustrated unique scenarios during the process.
The utility of far-infrared illumination in oxygenation dynamics as measured with near-infrared spectroscopy
(2012-10-01)
Wang, Chun-Yang
;
Chuang, Ming-Lung
;
Chuang, Ching-Cheng
;
Hsieh, Yao-Sheng
;
Sun, Chia-Wei
Near-infrared spectroscopy (NIRS) is a noninvasive method for measuring the oxygenation in muscle and other tissues in vivo. For quantitative NIRS measurement of oxygenation dynamics, the vessel-occlusion test was usually applied as physiological intervention. There are several drawbacks of the vessel-occlusion method that include skin contact, uncomfortable and microcirculation block of patients. Thus, we propose the far-infrared (FIR) illumination as a new physiological intervention method in this paper. Our preliminary result shows a linear correlation of oxygenation dynamic signals between FIR illumination and arterial-occlusion test (AOT) that implies the FIR illumination could be applied for hemodynamic response measurement in clinical diagnosis. ((c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)