Browsing by Author "Chuang, Ying-Sheng"

Now showing 1 - 1 of 1

A concise synthesis of 2-(2-aminothiophene)-benzimidazoles by one-pot multicomponent reaction
(2013)
Chen, Li-Hsun
;
Chuang, Ying-Sheng
;
Narhe, Bharat D.
;
Sun, Chung-Ming
;
應用化學系
A one-pot synthesis of 2-aminothiophene linked benzimidazoles was achieved by utilizing 2-cyanomethyl benzimidazoles in a modified Gewald multicomponent reaction. The synthetic strategy of the reaction involved treatment of 2-(cyanomethyl)-benzimdazole with aldehydes containing an active methylene group and sulfur powder under refluxing conditions. The multicomponent reaction proceeded via Knoevenagel condensation of 2-(cyanomethyl)-benzimdazole with aldehyde to generate an alpha,beta-unsaturated nitrile followed by cyclization with molecular sulfur under basic conditions to give biologically relevant 2-(2-aminothiophene)-benzimidazoles in good yields.