Browsing by Author "Dinh, Trung Anh"

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An Optimal Pin-Count Design With Logic Optimization for Digital Microfluidic Biochips
(2015-04-01)
Dinh, Trung Anh
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Yamashita, Shigeru
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Ho, Tsung-Yi
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資訊工程學系
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Department of Computer Science
Digital microfluidic biochips have become one of the most promising technologies for biomedical experiments. In modern microfluidic technology, reducing the number of independent control pins that reflects most of the fabrication cost, power consumption, and reliability of a microfluidic system, is a key challenge for every digital microfluidic biochip design. However, all the previous chip designs sacrifice the optimality of the problem, and only limited reduction on the number of control pins is observed. Moreover, most existing designs cannot satisfy high-throughput demand for bioassays, and thus inapplicable in practical contexts. In this paper, we propose the first optimal pin-count design scheme for digital microfluidic biochips. By integrating a very simple combinational logic circuit into the original chip, the proposed scheme can provide high-throughput for bioassays with an information-theoretic minimum number of control pins. Furthermore, to cope with the rapid growth of the chip\'s scale, we also propose a scalable and efficient heuristics to reduce the number of control pins. A logic optimization technique, which can be used to reduce the complexity of the integrated combinational logic circuit, is also presented in this paper. Experiments demonstrate that the proposed scheme can obtain much fewer number of control pins compared with the previous state-of-the-art works.
Control-Layer Optimization for Flow-Based mVLSI Microfluidic Biochips
(2014-01-01)
Hu, Kai
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Dinh, Trung Anh
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Ho, Tsung-Yi
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Chakrabarty, Krishnendu
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交大名義發表
Recent advantages in flow-based microfluidic biochips have enabled the emergence of lab-on-a-chip devices for bimolecular recognition and point-of-care disease diagnostics. However, the adoption of flow-based biochips is hampered today by the lack of computer-aided design tools. Manual design procedures not only delay product development but they also inhibit the exploitation of the design complexity that is possible with current fabrication techniques. In this paper, we present the first practical problem formulation for automated control-layer design in flow-based microfluidic VLSI (mVLSI) biochips and propose a systematic approach for solving this problem. Our goal is to find an efficient routing solution for control-layer design with a minimum number of control pins. The pressure-propagation delay, an intrinsic physical phenomenon in mVLSI biochips, is minimized in order to reduce the response time for valves, decrease the pattern set-up time, and synchronize valve actuation. Two fabricated flow-based devices and five synthetic benchmarks are used to evaluate the proposed optimization method. Compared with manual control-layer design and a baseline approach, the proposed approach leads to fewer control pins, better timing behavior, and shorter channel length in the control layer.